遗传 ›› 2012, Vol. 34 ›› Issue (5): 509-518.doi: 10.3724/SP.J.1005.2012.00509

• 综述 •    下一篇

5-羟甲基胞嘧啶的研究进展

张燕霞, 高可润, 禹顺英   

  1. 上海交通大学医学院附属精神卫生中心, 上海 200030
  • 收稿日期:2011-08-29 修回日期:2011-12-04 出版日期:2012-05-20 发布日期:2012-05-25
  • 通讯作者: 禹顺英 E-mail:yushuny@yahoo.com
  • 基金资助:

    国家自然科学基金项目(编号:81071094)资助

Progress of research on 5-hydroxymethylcytosine

ZHANG Yan-Xia, GAO Ke-Run, YU Shun-Ying   

  1. Shanghai Mental Health Center, School of Medicine,Shanghai Jiao Tong University, Shanghai 200030, China
  • Received:2011-08-29 Revised:2011-12-04 Online:2012-05-20 Published:2012-05-25
  • Contact: Shunying Yu E-mail:yushuny@yahoo.com

摘要: CpG二核苷酸中胞嘧啶的甲基化形式5-甲基胞嘧啶(5-methylcytosine, 5mC)在哺乳动物中是一种常见的表观遗传修饰, 在基因表达调控、发育调节、基因组印迹等方面发挥重要作用。近3年来研究发现, 除了5mC外, 胞嘧啶碱基的另一种修饰—5-羟甲基胞嘧啶(5-hydroxymethylcytosine, 5hmC)在哺乳动物的多种组织中有着丰富的表达, 它可能与5mC有着不同的生物学功能。文章就近年来5hmC的研究进展进行了综述。

关键词: 5-羟甲基胞嘧啶, TET蛋白, 表观遗传

Abstract: 5-methylcytosine (5mC) in cytosine-guanine dinucleotide (CpG) is a usual epigenetic modification in mammals. It plays crucial roles in gene regulation, development, genomic imprinting and so on. In the last three years, it was discovered that in addition to 5mC, another modified cytosine base—5-hydroxymethylcytosine (5hmC) was abundant in many mammalian tissues, which may have different biological function from 5mC. This paper reviews the recent progresses in the studies of 5hmC.

Key words: 5-hydroxymethylcytosine, TET protein, epigenetics