小鼠毛色遗传的控制机制及其在遗传学教学中的应用

doi:10.3724/SP.J.1005.2014.1062

遗传 ›› 2014, Vol. 36 ›› Issue (10): 1062-1068.doi: 10.3724/SP.J.1005.2014.1062

• 遗传学教学 • 上一篇

小鼠毛色遗传的控制机制及其在遗传学教学中的应用

邢万金,莫日根

内蒙古大学生命科学学院,呼和浩特 010021

收稿日期:2014-07-10 出版日期:2014-10-20 发布日期:2014-10-20
作者简介:邢万金,博士,教授,研究方向：分子遗传学和基因工程。Tel: 0471-4992944; E-mail: xwanjin@imu.edu.cn;莫日根,博士,教授,研究方向：DNA 复制调控与细胞周期。E-mail: morigenm@life.imu.edu.cn; 邢万金和莫日根同为第一作者。
基金资助:
内蒙古自治区生物化学系列课程教学团队建设项目和内蒙古自治区高等学校科学研究项目(NJZZ14001)资助

The genetic control of mouse coat color and its applications in gene-tics teaching

Wanjin Xing, Morigen

Department of Biology, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China

Received:2014-07-10 Online:2014-10-20 Published:2014-10-20

摘要/Abstract

摘要： 小鼠是最常用的哺乳动物模式生物,其毛色有白色、灰色、黄色、黑色等,是典型的孟德尔遗传性状。但在本科遗传学教学中,一般只在介绍隐性致死基因的时候才提到小鼠毛色遗传的例子。作者深入挖掘和整理了小鼠毛色遗传的分子机制,并把这个例子贯穿于讲解孟德尔遗传以及介绍分子遗传学的基因结构、基因功能、基因调控、基因互作、基因的表观遗传学修饰和数量性状遗传等,尝试用同一个案例贯穿本科遗传学教学,培养学生建立由表及里的系统分析能力,既凸显遗传学研究的前沿性和完整性,又吸引了学生的注意力,激发了学生的学习兴趣,收到了很好的教学效果。

关键词: 遗传学, 案例教学, 小鼠, 毛色

Abstract: Mice are the most commonly used mammalian model. The coat colors of mice are typical Mendelian traits, which have various colors such as white, black, yellow and agouti. The inheritance of mouse coat color is usually stated as an example only in teaching the knowledge of recessive lethal alleles. After searched the related literatures and summarized the molecular mechanisms of mouse coat color inheritance, we further expanded the application of this example into the introduction of the basic concepts of alleles and Mendelian laws, demonstration of the gene structure and function, regulation of gene expression, gene interaction, epigenetic modification, quantitative genetics, as well as evolutionary genetics. By running this example through the whole genetics-teaching lectures, we help the student to form a systemic and developmental view of genetic analysis. At the same time, this teaching approach not only highlights the advancement and integrity of genetics, but also results in a good teaching effect on inspiring the students’ interest and attracting students’ attention.

Key words: genetics, case-based teaching, mouse, coat color

邢万金,莫日根. 小鼠毛色遗传的控制机制及其在遗传学教学中的应用[J]. 遗传, 2014, 36(10): 1062-1068.

Wanjin Xing, Morigen. The genetic control of mouse coat color and its applications in gene-tics teaching[J]. HEREDITAS(Beijing), 2014, 36(10): 1062-1068.

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小鼠毛色遗传的控制机制及其在遗传学教学中的应用

The genetic control of mouse coat color and its applications in gene-tics teaching

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