细菌全基因组关联研究的方法与应用

doi:10.16288/j.yczz.17-303

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (1): 57-65.doi: 10.16288/j.yczz.17-303

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Bacterial genome-wide association study: methodologies and applications

Chao Yang(),Ruifu Yang,Yujun Cui

State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China

Received:2017-09-13 Revised:2017-10-30 Online:2018-01-20 Published:2017-12-15
Supported by:
the funding of the State Key Laboratory of Pathogen and Biosecurity(SKLPBS1405)

Abstract

Abstract:

With the development of genome sequencing and the accumulation of whole genome sequences, genome-wide association study (GWAS) has achieved remarkable advances in understanding of human complex disease, and tens of thousands of disease risk factors have been found. Meanwhile, GWAS provides a new tool for exploring the genetic mechanism of bacterial phenotypes. Since the publication of the first bacterial GWAS (BGWAS) work in 2013, there have been more than 10 reports, which reveal the genetic basis of host adaption, drug resistance and virulence, etc. These findings greatly enhance our understanding on genetics, evolution and spread of bacteria. In this review, we summarize the current methodologies, applications and problems of BGWAS and highlight its potential in future research, which aims to provide helps for the applications of BGWAS in the field of microbiology.

Key words: genome-wide association study, bacteria, whole genome sequencing, phenotype, genetic mechanism

Chao Yang, Ruifu Yang, Yujun Cui. Bacterial genome-wide association study: methodologies and applications[J]. Hereditas(Beijing), 2018, 40(1): 57-65.

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