m 6A修饰及其对病毒复制过程调控研究进展

doi:10.16288/j.yczz.19-042

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (5): 404-412.doi: 10.16288/j.yczz.19-042

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Advances in m ⁶A modification and its regulation of viral replication

Peng Xue¹,Tao Jiang¹,Xingjia Shen^1,²()

^1. Jiangsu Key Laboratory of Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212018, China
^2. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018, China

Received:2019-02-20 Revised:2019-04-08 Online:2019-05-20 Published:2019-04-16
Contact: Shen Xingjia E-mail:shenxjsri@163.com
Supported by:
National Natural Science Foundation of China(31672490);Natural Science Foundation of Jiangsu Province(BK20151322);Major Project of Natural Science Foundation for Universities of Jiangsu Province(15KJA180001)

Abstract

Abstract:

N ⁶-methyladenosine (m ⁶A) is a prevalent modification of RNA in eukaryotes and plays an important role in the process of mRNA translocation, stabilization and translation. m ⁶A exerts different influences on the viral replication cycle, and both viral replication and host immune response to the virus are affected by m ⁶A. In this review, we summarize recent studies on the mechanism of m ⁶A modification and its effects on viral replication and host immune response, in order to provide a reference for epigenetic regulation in the viral life cycle.

Key words: N ⁶-methyladenosine, RNA modification, virus, replication, immunity

Peng Xue, Tao Jiang, Xingjia Shen. Advances in m ⁶A modification and its regulation of viral replication[J]. Hereditas(Beijing), 2019, 41(5): 404-412.

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