云南傣族、汉族HLA-G基因14 bp插入/缺失多态性研究

doi:0.3724/SP.J.1005.2010.00577

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (6): 577-582.doi: 0.3724/SP.J.1005.2010.00577

Analysis of the 14 bp insertion/deletion polymorphism in human leukocyte antigen-G gene in Chinese Dai and Han ethnic groups in Yunnan Province

CHEN Jin-Bao^{1, 2}, SHI Lei¹, YAO Yu-Feng¹, SHI Li¹, YU Liang¹, LIN Ke-Qin¹, TAO Yu-Fen¹, YI Wen¹,
HUANG Xiao-Qin¹, SUN Hao¹, CHU Jia-You¹

1. Department of Medical Genetics, Institute of Medical Biology, Chinese Acadamy of Medical Sciences & Peking Union Medical College, Kunming 650118, China;
2. Kunming Medical College, Kunming 650031, China

Received:2009-11-03 Revised:2009-12-29 Online:2010-06-20 Published:2010-05-24
Contact: CHU Jia-You E-mail:chujy@imbcams.com.cn

Abstract

Abstract:

A 14 bp insertion/deletion polymorphism (+14 bp/-14 bp) in exon 8 of HLA-G gene has been investigated extensively because this polymorphism was associated with HLA-G mRNA stability and could influence HLA-G mRNA expression. In the present study, we genotyped 14 bp insertion/deletion polymorphisms in the HLA-G gene in Dai and Han populations in Yunnan Province. The frequencies of +14 bp in Dai and Han were 31.97% and 40.87%, respectively. The frequency of +14 bp/+14 bp in Dai was lower (8.20%) than that of Han (17.31%). Nevertheless, the frequency of +14 bp/-14 bp was similar in both populations (47.54% in Dai and 47.11% in Han). When compared with other populations, the frequency of 14 bp insertion/deletion of Han was similar to others, whereas the Dai showed significent difference from others and presented it’s specific characteristic. We assumed that the distributaion characteristic of 14 bp insertion/deletion in Dai might be the results of random genetic drift, but the role of natural selection cannot be excluded.

Key words: HLA-G gene, 14 bp insertion/deletion polymorphism, random genetic drift, natural selection

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Analysis of the 14 bp insertion/deletion polymorphism in human leukocyte antigen-G gene in Chinese Dai and Han ethnic groups in Yunnan Province

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