Sp1/Krüppel样因子的研究进展

doi:10.3724/SP.J.1005.2010.00531

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (6): 531-538.doi: 10.3724/SP.J.1005.2010.00531

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Progress on Sp1-like and Krüppel-like factors

XIONG Qian^1,2, RUAN Xiu-Yan¹, FANG Xiang-Dong¹

1．Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China; 2．Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2009-09-15 Revised:2009-10-27 Online:2010-06-20 Published:2010-05-24
Contact: FANG Xiang-Dong E-mail:fangxd@big.ac.cn

Abstract

Abstract:

Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this arti-cle, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.

Key words: Sp1-like and Krüppel-like factors, zinc-finger domain, transcriptional regulating

XIONG Qian, RUAN Xiu-Yan, FANG Xiang-Dong. Progress on Sp1-like and Krüppel-like factors[J]. HEREDITAS, 2010, 32(6): 531-538.

References

[1] Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Krüppel-like transcription factors: a functional family. Int J Biochem Cell Biol, 2008, 40(10): 1996–2001.

[2] Dynan WS, Tjian R. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell, 1983, 35(1): 79–87.

[3] Schuh R, Aicher W, Gaul U, Côté S, Preiss A, Maier D, Seifert E, Nauber U, Schröder C, Kemler R, Jäckle H. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell, 1986, 47(6): 1025–1032.

[4] Kaczynski J, Cook T, Urrutia R. Sp1- and Krüppel-like transcription factors. Genome Biol, 2003, 4(2): 206.1–206.8.

[5] Shields JM, Yang VW. Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins. J Biol Chem, 1997, 272(29): 18504–18507.

[6] Fujimura N, Vacik T, Machon O, Vlcek C, Scalabrin S, Speth M, Diep D, Krauss S, Kozmik Z. Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J Biol Chem, 2007, 282(2): 1225–1237. [7] Basu P, Lung TK, Lemsaddek W, Sargent TG, Williams DC Jr, Basu M, Redmond LC, Lingrel JB, Haar JL, Lloyd JA. EKLF and KLF2 have compensatory roles in embryonic β-globin gene expression and primitive erythropoiesis. Blood, 2007, 110(9): 3417–3425.

[8] McConnell BB, Ghaleb AM, Nandan MO, Yang VW. The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays, 2007, 29(6): 549–557.

[9] Eaton SA, Funnell AP, Sue N, Nicholas H, Pearson RC, Crossley M. A network of Krüppel-like factors (Klfs). J Biol Chem, 2008, 283(40): 26937–26947.

[10] Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH. Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. J Biol Chem, 2006, 281(51): 39105–39113.

[11] Chen X, Bieker JJ. Stage-specific repression by the EKLF transcriptional activator. Mol Cell Biol, 2004, 24(23): 10416–10424.

[12] Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol, 2009, 29(10): 2483–2488.

[13] Quadrini KJ, Bieker JJ. EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome. FEBS Lett, 2006, 580(9): 2285–2293.

[14] Perdomo J, Verger A, Turner J, Crossley M. Role for SUMO modification in facilitating transcriptional repres-sion by BKLF. Mol Cell Biol, 2005, 25(4): 1549–1559.

[15] Lomberk G, Urrutia R. The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J, 2005, 392(Pt 1): 1–11.

[16] Quadrini KJ, Gruzglin E, Bieker JJ. Non-random subcel-lular distribution of variant EKLF in erythroid cells. Exp Cell Res, 2008, 314(7): 1595–1604.

[17] Bouwman P, Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol, 2002, 195(1–2): 27–38.

[18] Zhao C, Meng A. Sp1-like transcription factors are regu-lators of embryonic development in vertebrates. Dev Growth Differ, 2005, 47(4): 201–211.

[19] Asano H, Li XS, Stamatoyannopoulos G. FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes. Blood, 2000, 95(11): 3578–3584.

[20] Feng D, Kan YW. The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of β-like globin genes.

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Progress on Sp1-like and Krüppel-like factors

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