帕金森病相关基因功能研究进展

doi:10.3724/SP.J.1005.2010.00779

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (8): 779-784.doi: 10.3724/SP.J.1005.2010.00779

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Function study advances of Parkinson¢s disease related genes

WANG Xiang-Ming, WANG Dan-Qiao, WANG Xiao-Yan

China Academy of Chinese Medical Science, the Experimental Research Center, Beijing 100700, China

Received:2009-11-24 Revised:2010-03-19 Online:2010-08-20 Published:2010-08-23
Contact: WANG Dan-Qiao E-mail:dq_wang96@hotmail.com

Abstract

Abstract: Parkinson¢s disease (PD) is a common extrapyramidal disease, of which the cardinal symptoms are hypokinesia, muscular rigidity, and tremor. The main pathological characteristics of this disease are loss of dopamine neurons in substantia nigra pars compacta, and residual neurons often contain Lewy bodies. The PD pathogenesis is still not well known, while it is generally recognized that age and environmental factors participate in it. In recent years, genetic research on PD has made considerable progresses that genetic factors play important roles on the pathogenesis of PD, and multiple PD related genes, such as SNCA, LRRK2, PINK1, parkin, UCHL1, and DJ1, have been identified. This article summarizes recent progresses on these genes to provide reference for PD study.

Key words: genetics, gene function, molecular mechanism, Parkinson’s disease

WANG Xiang-Meng, WANG Dan-Qiao, HONG Xiao-Yan. Function study advances of Parkinson¢s disease related genes[J]. HEREDITAS, 2010, 32(8): 779-784.

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Function study advances of Parkinson¢s disease related genes

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