特异AT序列结合蛋白2(SATB2)的研究进展

doi:10.3724/SP.J.1005.2011.00947

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (9): 947-952.doi: 10.3724/SP.J.1005.2011.00947

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Study progress of special AT-rich sequence binding protein 2

QIAN Yan-Yan^1,2, WANG Hui-Jun², MA Duan^1,2

1. Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China 2. Institutes of Biomedical Science, Resaerch Center for Birth Defects, Fudan University, Shanghai 200032, China

Received:2010-11-12 Revised:2010-12-07 Online:2011-09-20 Published:2011-09-25

Abstract

Abstract: SATB2 is a transcription factor, which plays an important role in transcriptional regulation and chromatin recombinant by combining with matrix attachment regions. SATB2 is a key regulatory molecule in the progress of osteoblast differentiation and bone matrix formation. Mutations in this gene are associated with congenital craniofacial malformation. In addition, SATB2 is involved in the development of central nervous system, especially the corpus callosum and the pons. At the same time, SATB2 may participate in the process of tumor formation. In malignant tumors, such as breast cancer, the expression level of SATB2 is higher than normal. The literatures of SATB2 were reviewed in this article.

Key words: SATB2, regulator, bone development, central nervous system development, tumor

JIAN Yan-Yan, WANG Hui-Jun, MA Duan. Study progress of special AT-rich sequence binding protein 2[J]. HEREDITAS, 2011, 33(9): 947-952.

References

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Study progress of special AT-rich sequence binding protein 2

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