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HEREDITAS ›› 2012, Vol. 34 ›› Issue (4): 389-400.doi: 10.3724/SP.J.1005.2012.00389

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Function of SM protein in vesicle transport

ZHAO Xiang, HAN Bao-Da, LI Li-Xin   

  1. Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education, Alkali Soil Natural Environ-mental Science Center, Northeast Forestry University, Harbin 150040, China
  • Received:2011-10-18 Revised:2011-11-24 Online:2012-04-20 Published:2012-04-25

Abstract: Most cells contain various transport vesicles that target to different destinations. The underlying molecular mechanisms are highly conserved in evolution. Sec1/Munc-18 (SM) proteins play an important role on regulating vesicle transport by interacting with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion sites. SM proteins interact with syntaxin, an important component in SNARE complex, to regulate the assembly of SNARE complex, and promote overall membrane fusion process together with SNARE complex. This review summaries new research progresses of structure and function of SM protein.

Key words: vesicle transprot, membrane fusion, SNARE protein, SM protein