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HEREDITAS ›› 2012, Vol. 34 ›› Issue (9): 1133-1143.doi: 10.3724/SP.J.1005.2012.01133

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Advances in the zebrafish circadian clock mechanisms

WANG Ming-Yong, HUANG Guo-Dong, WANG Han   

  1. Center for Circadian Clocks, Medical College, Soochow University, Suzhou 215123, China
  • Received:2012-03-03 Revised:2012-05-02 Online:2012-09-20 Published:2012-09-25

Abstract: Zebrafish has recently become an emerging vertebrate model for circadian studies. Here we summarized recent advances in the field of zebrafish circadian research. The characteristics and advantages of zebrafish as a circadian model, as well as its time-keeping mechanisms, were highlighted. Because light and temperature as external time cues both play important roles in the circadian regulation of zebrafish, we focused on recent studies concerning the effects of light and temperature on circadian clock genes and circadian regulatory pathways in zebrafish. We also provided the perspectives on prospective zebrafish circadian studies.

Key words: circadian clocks, negative feedback loop, light regulation, temperature compensation, zebrafish