质膜组分磷脂酰丝氨酸外翻的分子调控机制

doi:10.16288/j.yczz.14-207

[an error occurred while processing this directive]

HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (2): 140-147.doi: 10.16288/j.yczz.14-207

• Reviews • Previous Articles Next Articles

Molecular regulations of phosphatidylserine eversion in plasma membrane

Dan Bi^1,2,Yang Xu^1,2,Yue Pang^1,2,Qingwei Li^1,2

1. College of Life Science, Liaoning Normal University, Dalian 116029, China;
2. Lamprey Research Center, Liaoning Normal University, Dalian 116029, China

Received:2014-06-25 Online:2015-02-20 Published:2015-01-19

Abstract

Abstract: Phosphatidylserine (PS), one important phospholipid of cell membranes, has crucial biological functions. Under special pathological circumstances such as cell apoptosis, cells cannot generate enough ATP for energy and the concentration of cytoplasmic Ca²⁺ increases, resulting in PS eversion. PS eversion has different biological functions in different cell types. In addition, the degree of eversion is closely associated with the progress of diseases. Therefore, it can be therapeutic targets of cancer and many other diseases. In this review, we summarize the fundamental biological functions of PS, molecular mechanisms of PS eversion, as well as its potential in translational medicine.

Key words: phosphatidylserine, target molecules, apoptosis, phosphatidylserine eversion

Dan Bi,Yang Xu,Yue Pang,Qingwei Li. Molecular regulations of phosphatidylserine eversion in plasma membrane[J]. HEREDITAS(Beijing), 2015, 37(2): 140-147.

References

[1] 王镜岩, 朱圣庚, 徐长法. 生物化学. 北京: 高等教育出版社, 2002.
[2] Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem , 1957, 226(1): 497-509.
[3] Baer E, Maurukas J. Phosphatidyl serine . J Biol Chem , 1955, 212(1): 25-38.
[4] Chu C, Huang X, Chen CT, Zhao Y, Luo JJ, Gray BD, Pak KY, Dun NJ. In vivo imaging of brain infarct with the novel fluorescent probe PSVue 794 in a rat middle cerebral artery occlusion-reperfusion model. Mol Imaging , 2013, 12(1): 8-16.
[5] Lin QQ, London E. Preparation of artificial plasma membrane mimicking vesicles with lipid asymmetry. PLoS One , 2014, 9(1): e87903.
[6] Haberkorn U, Markert A, Mier W, Askoxylakis V, Altmann A. Molecular imaging of tumor metabolism and apoptosis. Oncogene , 2011, 30(40): 4141-4151.
[7] Seigneuret M, Devaux PF. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. Proc Natl Acad Sci USA , 1984, 81(12): 3751-3755.
[8] Haest CWM. Distribution and movement of membrane lipids. In: Bernhardt I, Ellory C. Red Cell Membrane Transport in Health and Disease. Berlin Heidelberg: Springer, 2003: 1-25.
[9] Ran S, Downes A, Thorpe PE. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res , 2002, 62(21): 6132-6140.
[10] Kroy DC, Ciuffreda D, Cooperrider J H, Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology , 2014, 146(2): 550-561.
[11] Ravichandran KS. Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity , 2011, 35(4): 445-455.
[12] Caberoy NB, Alvarado G, Bigcas JL, Li W. Galectin-3 is a new MerTK-specific eat-me signal. J Cell Physiol , 2012, 227(2): 401-407.
[13] Dong HP, Holth A, Kleinberg L, Ruud MG, Elstrand MB, Tropé CG, Davidson B, Risberg B. Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the annexin-V/7-AAD assay clinical relevance and comparison with other apoptosis parameters. Am J Clin Pathol , 2009, 132(5): 756-762.
[14] Jilani K, Enkel S, Bissinger R, Almilaji A, Abed M, Lang F. Fluoxetine induced suicidal erythrocyte death. Toxins (Basel) , 2013, 5(7): 1230-1243.
[15] Bhavsar SK, Bobbala D, Xuan NT, Föller M, Lang F. Stimulation of suicidal erythrocyte death by α-lipoic acid. Cell Physiol Biochem , 2010, 26(6): 859-868.
[16] Jilani K, Lang F. Carmustine-induced phosphatidylserine translocation in the erythrocyte membrane. Toxins (Basel) , 2013, 5(4): 703-716.
[17] Weiss E, Rees DC, Gibson JS. Role of calcium in phosphatidylserine externalisation in red blood cells from sickle cell patients. Anemia , 2010, 7(4): 1-8.
[18] 刘述川, 周晋, 史家岚, 苏雁华. 正常血细胞表面磷脂酰丝氨酸的表达及其促凝功能. 中华血液学杂志, 2011, 32(12): 858-862.
[19] Laliberte JP, Moss B. Appraising the apoptotic mimicry model and the role of phospholipids for poxvirus entry. Proc Natl Acad Sci USA , 2009, 106(41): 17517-17521.
[20] Farias LH, Rodrigues A P, Silveira FT, Seabra SH, DaMatta RA, Saraiva EM, Silva EO. Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis. J Infect Dis , 2013, 207(3): 537-543.
[21] Rochael NC, Lima LG, Oliveira SM, Barcinski MA, Saraiva EM, Monteiro RQ, Pinto-da-Silva LH. Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva. Mem Inst Oswaldo Cruz , 2013, 108(6): 679-685.
[22] Riedl S, Rinner B, Asslaber M, Schaider H, Walzer S, Novak A, Lohner K, Zweytick D. In search of a novel target—phosp

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Molecular regulations of phosphatidylserine eversion in plasma membrane

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Cuiling Wang, Xinyi Liu, Yahui Wang, Zheng Zhang, Zhidong Wang, Gangqiao Zhou. MCM2 promotes the proliferation, migration and invasion of cholangiocarcinoma cells by reducing the p53 signaling pathway [J]. Hereditas(Beijing), 2022, 44(3): 230-244.
[2]	Wanyin Chen, Yidan Yan, Xiaojin Luan, Min Wang, Jie Fang. Functional analysis of CG8005 gene in Drosophila testis [J]. Hereditas(Beijing), 2020, 42(11): 1122-1132.
[3]	Zhongyong Qin, Xiao Shi, Pingping Cao, Ying Chu, Wei Guan, Nan Yang, He Cheng, Yujie Sun. The NOXA promoter could function as an active enhancer to regulate the expression of BCL2 in the apoptosis response [J]. Hereditas(Beijing), 2020, 42(11): 1110-1121.
[4]	Tonglu YU,Dongliang Cai,Genfeng Zhu,Xiaojuan Ye,Taishan Min,Hongyan Chen,Daru Lu,Haoming Chen. Effects of CSN4 knockdown on proliferation and apoptosis of breast cancer MDA-MB-231 cells [J]. Hereditas(Beijing), 2019, 41(4): 318-326.
[5]	Maoliang Ran, Lianhua Dong, Bo Weng, Rong Cao, Fuzhi Peng, Hu Gao, Hui Luo, Bin Chen. miR-362 regulates the proliferation and apoptosis of porcine immature Sertoli cells through targeting the ZNF644 gene [J]. Hereditas(Beijing), 2018, 40(7): 572-584.
[6]	Jianyuan Zhao, Jiwei Ding, Zeyun Mi, Jinming Zhou, Tao Wei, Shan Cen. Genetic variance in the HIV-1 founder virus Vpr affects its ability to induce cell cycle G₂ arrest and cell apoptosis [J]. HEREDITAS(Beijing), 2015, 37(5): 480-486.
[7]	Lei Zhang, Yu Sui, Ting Wang, Lijian Li, Yuanjie Li, Caixia Jin, Fang Xu. Roles of hMMS2 gene in reversing the oxaliplatin tolerance of hu-man colon carcinoma cells [J]. HEREDITAS, 2014, 36(4): 346-353.
[8]	GUO Yun-Xue, MO De-Lin, CHEN Yao-Sheng, ZHANG Yue, ZHANG Yun, XIAO Shu-Qi, LIU Xiao-Hong. Effects of PI3K/AKT inhibitor wortmannin on proliferation and apoptosis of primary porcine preadipocytes [J]. HEREDITAS, 2012, 34(10): 1282-1290.
[9]	WANG Shi-Yao, JIN Wei-Na, WU Dan. Mechanisms of juvenile neuronal ceroid lipofuscinosis (JNCL) [J]. HEREDITAS, 2009, 31(8): 779-784.
[10]	MA Xiang-Dong, MA Xing, WU Xiao-Ming, CHEN Bi-Liang, WANG De-Tangx. Differentially expressed genes in diabetes-induced embryopathy [J]. HEREDITAS, 2009, 31(3): 280-284.
[11]	GUO Fen, LUO Zhi-Wen, LIU Zhao-Yu, LI Ru-Qin, LI Hong-Jian, ZHOU Tian-Hong. Studies of effect of prosaposin on cell proliferation, cell apoptosis and its possible molecular mechanism [J]. HEREDITAS, 2009, 31(12): 1226-1232.
[12]	FU Hao, ZHAO Dan-Yi, SUN Xiu-Ju, HUA Jun, YAN Yang, QIU Guang-Rong, SHANG Chao, FU Wei-Neng, SUN. Effect of B-RAF-specific RNA interference on gastric cancer BGC823 cell line [J]. HEREDITAS, 2007, 29(5): 537-537―540.
[13]	WANG Lin, LIANG Xu-Fang, LIAO Wan-Qin, ZHOU Tian-Hong. Research Progress on Cell Apoptosis in Embryonic Development of Zebrafish (Danio rerio) [J]. HEREDITAS, 2006, 28(8): 1009-1014.
[14]	WANG Zhen-Xing, WANG Pu, YAO Ling, ZENG Zhi-Dong, XU Han-Fu, DUAN Jun, WANG Gen-Hong, XIA Qing-You. Molecular Cloning, Sequence and Function Analyses and Specific Expression of Gene BmICAD Related to Apoptosis in Silkworm, Bombyx mori [J]. HEREDITAS, 2006, 28(7): 838-844.
[15]	LI Yan-FenG, ZHANG Qiang, ZHU Da-Hai. The Ubiquitin-Proteasome Proteolytic Pathway and Tumorigenesis [J]. HEREDITAS, 2006, 28(12): 1591-1591~1596.