miRNA介导PGR信号通路在雌性生殖功能调节中的作用机制

doi:10.16288/j.yczz.15-293

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HEREDITAS(Beijing) ›› 2016, Vol. 38 ›› Issue (1): 40-51.doi: 10.16288/j.yczz.15-293

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The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction

Long Chen¹, Baoyun Zhang¹, Guangde Feng², Wei Xiang¹, Yunxia Ma¹, Hang Chen¹, Mingxing Chu³, Pingqing Wang¹

1. Bioengineering Institute of Chongqing University, Chongqing 400030, China;
2. Sichuan TQLS Animal Husbandry Science and Technology Co., LTD, Mianyang 621000, China;
3. Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2015-06-24 Revised:2015-09-05 Online:2016-01-20 Published:2016-01-20
Supported by:
[Supported by the National Natural Science Foundation of China (No; 31372287), the Major Projects of Development and Reform Commission (No; 2014-2573), the National Science and Technology Major Projects of China (No; 2014ZX0800952B), Chinese Academy of Agricultural Science and Technology Innovation Project (No; ASTIP-IAS13)]

Abstract

Abstract: MicroRNAs (miRNAs) are involved in several physiological processes as important post-transcriptional regulators. Progesterone (P4), an important steroid hormone, produces physiological effect through binding specific receptor progesterone receptors (PGR) which regulates functions of both reproductive and non-reproductive tissues as a member of the nuclear receptor superfamily. P4/PGR and miRNAs could regulate female reproduction independently, however, it is still unclear how miRNAs and P4/PGR interaction regulates female reproductive activities such as ovulation in female reproduction. In this review, we summarize the possible ways in which miRNAs regulate P4 production and PGR gene expression as well as P4/PGR regulate miRNAs expression, which provide a theoretical basis for further studying the role of miRNAs and P4/PGR in female reproduction.

Key words: miRNA, progesterone, progesterone receptor, female reproduction

Long Chen, Baoyun Zhang, Guangde Feng, Wei Xiang, Yunxia Ma, Hang Chen, Mingxing Chu, Pingqing Wang. The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction[J]. HEREDITAS(Beijing), 2016, 38(1): 40-51.

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The mechanism of miRNA-mediated PGR signaling pathway in regulating female reproduction

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