群体感应与微生物耐药性

doi:10.16288/j.yczz.16-141

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Hereditas(Beijing) ›› 2016, Vol. 38 ›› Issue (10): 881-893.doi: 10.16288/j.yczz.16-141

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Quorum sensing and microbial drug resistance

Yufan Chen^{1, 2}, Shiyin Liu^{1, 2}, Zhibin Liang^{1, 2}, Mingfa Lv^{1, 2}, Jianuan Zhou^{1, 2}, Lianhui Zhang^{1, 2}

1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China;
2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China

Received:2016-04-20 Revised:2016-06-20 Online:2016-10-20 Published:2016-10-20
Supported by:
[Supported by the National Basic Research Program of China (973 Program) (No; 2015CB150600) and the National Natural Science Foundation of China (Nos; 31330002, 31270170)]

Abstract

Abstract: Microbial drug resistance has become a serious problem of global concern, and the evolution and regulatory mechanisms of microbial drug resistance has become a hotspot of research in recent years. Recent studies showed that certain microbial resistance mechanisms are regulated by quorum sensing system. Quorum sensing is a ubiquitous cell-cell communication system in the microbial world, which associates with cell density. High-density microbial cells produce sufficient amount of small signal molecules, activating a range of downstream cellular processes including virulence and drug resistance mechanisms, which increases bacterial drug tolerance and causes infections on host organisms. In this review, the general mechanisms of microbial drug resistance and quorum-sensing systems are summarized with a focus on the association of quorum sensing and chemical signaling systems with microbial drug resistance mechanisms, including biofilm formation and drug efflux pump. The potential use of quorum quenching as a new strategy to control microbial resistance is also discussed.

Key words: microbial drug resistance, quorum sensing, biofilm formation, quorum quenching, drug efflux pump

Yufan Chen, Shiyin Liu, Zhibin Liang, Mingfa Lv, Jianuan Zhou, Lianhui Zhang. Quorum sensing and microbial drug resistance[J]. Hereditas(Beijing), 2016, 38(10): 881-893.

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