长链非编码RNA——抗病毒天然免疫应答的新兴调控因子

doi:10.16288/j.yczz.18-065

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (7): 525-533.doi: 10.16288/j.yczz.18-065

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Long non-coding RNAs: Emerging regulators of antiviral innate immune responses

Huawei Zhang^1,²,Xingyu Meng¹,anfeng Li¹,Yuying Yang²,Huaji Qiu¹()

^1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
^2. College of Animal Sciences, Yangtze University, Jingzhou 434023, China

Received:2018-03-13 Revised:2018-04-12 Online:2018-07-20 Published:2018-06-08
Supported by:
Supported by the National Natural Science Foundation of China(31700139)

Abstract

Abstract:

Long non-coding RNAs (lncRNAs) are designated as the transcripts longer than 200 nucleotides without protein-coding capacity. As a category of important gene regulatory factors, lncRNAs regulate the expression of target genes at epigenetic, transcription and post-transcriptional levels by various mechanisms, such as chromatin remodeling, DNA modification, transcription inhibition and RNA-RNA interactions, etc. In recent years, studies have shown that many lncRNAs can be induced by viruses or interferon (IFN) and to regulate the expression of related antiviral genes in IFN-mediated antiviral innate immune responses. In this review, we focus on the regulation of lncRNAs in IFN-mediated antiviral innate immune responses, especially in the transcription of IFN-stimulated genes (ISGs). In addition, we summarize the regulatory network of lncRNAs, IFN and ISGs. This review will provide a valuable reference for the researchers working in this field.

Key words: long non-coding RNAs, interferon, interferon-stimulated genes, antiviral innate immune response

Huawei Zhang, Xingyu Meng, anfeng Li, Yuying Yang, Huaji Qiu. Long non-coding RNAs: Emerging regulators of antiviral innate immune responses[J]. Hereditas(Beijing), 2018, 40(7): 525-533.

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