MicroRNA调控耳蜗毛细胞发育的分子机制

doi:10.16288/j.yczz.19-119

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (11): 994-1008.doi: 10.16288/j.yczz.19-119

• Review • Previous Articles Next Articles

Molecular mechanism of microRNA in regulating cochlear hair cell development

Lin Rao, Feilong Meng, Ran Fang, Chenyi Cai, Xiaoli Zhao()

Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Institute of Genetics and Regenerative Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Received:2019-07-20 Revised:2019-09-26 Online:2019-11-20 Published:2019-10-18
Contact: Zhao Xiaoli E-mail:zhaoxiaoli@zju.edu.cn
Supported by:
Supported by the National Program on Key Basic Research Project (973 Program) No(2012CB967900)

Abstract

Abstract:

Deafness has become one of the most frequent health problems worldwide, and affects almost every age group. Hair cell damage or absence is the main cause of hearing loss, but there is no successful treatment to heal deafness. MicroRNA (miRNA), as a highly conserved endogenous non-coding small RNA, plays an important role in inner ear cochlea and hair cell development. In this review, we elaborate on the expression and function of miRNAs in cochlear hair cell development, and reveal its indispensable important role. We summarize the molecular mechanism of miRNA in regulating transcription factors involved in cochlear hair cell development, which may provide references and insights for hair cell regeneration in vivo and cellular transplantation therapy of deafness.

Key words: miRNA, cochlea, hearing loss, hair cells

Lin Rao, Feilong Meng, Ran Fang, Chenyi Cai, Xiaoli Zhao. Molecular mechanism of microRNA in regulating cochlear hair cell development[J]. Hereditas(Beijing), 2019, 41(11): 994-1008.

Figures/Tables 5

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Molecular mechanism of microRNA in regulating cochlear hair cell development

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miRNA	靶基因	参考文献
miR-9	COL9A1	[72]
miR-29	SIRT1	[80]
miR-34a	SIRT1、bcl-2和E2F-3	[80]
miR-96	TRK和EGFR	[52]
miR-96	Slc26a5、Ocm、Gfi1、Ptprq和Pitpnm1	[59]
miR-96/-182	CLIC5	[73]
miR-124	Sfrp4和Sfrp5	[74]
miR-135b	PSIP1-P75	[82]
miR-140	NR2F1和Klf9	[83]
miR-182	Sox2和Tbx1	[84]
miR-183	Taok1和ltgA3	[70]
miR-194	Fgf4和RhoB	[76]
miR-200	Zeb1和Zeb2	[85]
miR-204	TMPRSS3	[86]
miR-224	Ptx3	[87]
miR-376	PRPS1	[78]

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