RNAi在抗蚊媒病毒感染中的研究进展

doi:10.16288/j.yczz.19-262

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (2): 153-160.doi: 10.16288/j.yczz.19-262

• Review • Previous Articles Next Articles

Research progress in RNA interference against the infection of mosquito-borne viruses

Yong Wei(), Yulan He, Xueli Zheng()

Department of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou 510515, China

Received:2019-10-15 Revised:2019-12-14 Online:2020-01-02 Published:2020-01-07
Supported by:
National Natural Science Foundation of China(31630011);Natural Science Foundation of Guangdong Province of China(2017A030313625);Science and Technology Planning Project of Guangzhou City(201804020084)

Abstract

Abstract:

Mosquito-borne diseases have become an important public health issue of global concern because of their high incidence and transmission rate. As a vector for mosquito-borne diseases, studying the interaction mechanism between mosquitoes and mosquito-borne viruses will help control mosquito-borne diseases. The impaired innate immunity and immune barriers evasion caused by mosquito-borne viruses in mosquitoes pose a potential risk for the persistent infection of the virus in mosquitoes and the outbreak of mosquito-borne diseases. The RNA interference (RNAi) pathway, as a powerful antiviral defense barrier in mosquitoes, can inhibit viral replication and transmission by producing a variety of small RNAs to degrade viral RNA. In this review, we summarize the related studies on the innate immune mechanism against mosquito- borne virus infection in mosquitoes about small interfering RNA (siRNA), microRNA (miRNA), and Piwi-interacting RNA (piRNA), aiming to provide a theoretical reference for the prevention and control of mosquito-borne diseases.

Key words: Mosquito, Mosquito-borne viruses, siRNA, miRNA, piRNA

Yong Wei, Yulan He, Xueli Zheng. Research progress in RNA interference against the infection of mosquito-borne viruses[J]. Hereditas(Beijing), 2020, 42(2): 153-160.

Figures/Tables 3

References 60

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Research progress in RNA interference against the infection of mosquito-borne viruses

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