大熊猫(Ailuropoda melanoleuca) miRNA研究进展

doi:10.16288/j.yczz.21-209

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (9): 849-857.doi: 10.16288/j.yczz.21-209

• Review • Previous Articles Next Articles

Progress on miRNA in giant panda (Ailuropoda melanoleuca)

Yan Zhu, Ming Wei, Xiao Zhou, Linhua Deng, Jian Qiu, Guo Li, Shiqiang Zhou, Hao Xie, Desheng Li, Chengdong Wang()

State Forestry and Grassland Administration Key Laboratory of Conservation Biology for Rare Animals of the Giant Panda State Park, China Conservation and Research Center for the Giant Panda, Chengdu 611830, China

Received:2021-06-11 Revised:2021-07-28 Online:2021-09-20 Published:2021-08-23
Contact: Wang Chengdong E-mail:wolongpanda@qq.com
Supported by:
Supported by Giant Panda International Cooperation Fund Project No(GH201710)

Abstract

Abstract:

MicroRNAs (miRNAs), a family of endogenous non-coding RNAs with a length of about 22 nucleotides, are widely found in eukaryotes. miRNAs can affect gene expression through specific bindings with mRNAs of target genes and participate in the regulation of a variety of biological processes. Giant panda is not only a unique rare animal in China, but also the focus of attention on wildlife preservation worldwide. In recent years, with the popularization of next-generation sequencing (NGS) technology, miRNAs in giant panda have been discovered and identified one after another. In this review, we focus on the research progress on miRNAs in giant panda, involved in immune response, mammary gland development, sperm freezing tolerance and other biological processes, and then discuss future research directions of miRNAs in giant panda, and thus providing the scientific references and new ideas for studying the regulatory mechanisms of miRNAs and promoting the breeding and protection of giant panda.

Key words: giant panda, miRNA, immune response, mammary gland development, sperm freezing tolerance

Yan Zhu, Ming Wei, Xiao Zhou, Linhua Deng, Jian Qiu, Guo Li, Shiqiang Zhou, Hao Xie, Desheng Li, Chengdong Wang. Progress on miRNA in giant panda (Ailuropoda melanoleuca)[J]. Hereditas(Beijing), 2021, 43(9): 849-857.

Figures/Tables 2

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生物学功能	组织	研究策略	参考文献
调控免疫反应,包括血液免疫、母乳免疫	血液、乳汁	对不同年龄大熊猫的血液进行miRNA-seq;对接种犬瘟热病毒疫苗后的大熊猫血液进行miRNA-seq;对不同哺乳期的大熊猫母乳外泌体进行miRNA-seq	[36,38,42]
调控乳腺发育及新生幼崽生长发育	血液、乳汁	对怀孕后期和哺乳早期大熊猫血液进行miRNA-seq;对不同哺乳期母乳外泌体进行miRNA-seq	[37,38]
调控精子冷冻耐受	精子	对大熊猫新鲜和冷冻的精子外泌体进行miRNA-seq	[40]
调控其他多种生物学过程	内脏(心、肝、脾、肺、肾)	对不同内脏组织进行miRNA-seq;对新生和成年大熊猫的脾脏进行miRNA-seq	[39,41]

Progress on miRNA in giant panda (Ailuropoda melanoleuca)

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