Supported by the National Key R&D Program of China Nos(2017YFA0504400);Supported by the National Key R&D Program of China Nos(2021YFC2700200);Supported by the National Key R&D Program of China Nos(2017YFA0504400);Supported by the National Key R&D Program of China Nos(2021YFC2700200);the National Natural Science Foundation of China Nos(91940305);the National Natural Science Foundation of China Nos(31830109);the National Natural Science Foundation of China Nos(31821004);the National Natural Science Foundation of China Nos(32171186);the National Natural Science Foundation of China Nos(91940302);the National Natural Science Foundation of China Nos(31961133022);the National Natural Science Foundation of China Nos(32170815);the National Natural Science Foundation of China Nos(91640201);the Strategic Priority Research Program of Chinese Academy of Sciences No(XDB19010203);the Science and Technology Commission of Shanghai Municipality Nos(2017SHZDZX01);the Science and Technology Commission of Shanghai Municipality Nos(19JC1410200);the Science and Technology Commission of Shanghai Municipality Nos(17JC1420100);the Science and Technology Commission of Shanghai Municipality Nos(21PJ1413800);the Science and Technology Commission of Shanghai Municipality Nos(21ZR1470200);the Innovative Research Team of High-level Local Universities in Shanghai No(SHSMU-ZDCX20210902);the National Postdoctoral Program for Innovative Talent Grant Nos(BX20180331);the National Postdoctoral Program for Innovative Talent Grant Nos(BX20190081);China Postdoctoral Science Foundation Nos(2018M642018);China Postdoctoral Science Foundation Nos(2020M670986);the Open Fund of State Key Laboratory of Reproductive Medicine No(SKLRM-K202101);the Foundation of Key Laboratory of Gene Engineering of the Ministry of Education