生酮饮食激活脂肪酸氧化促进ME区的少突胶质细胞前体细胞增殖

doi:10.16288/j.yczz.23-026

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (5): 425-434.doi: 10.16288/j.yczz.23-026

• Research Article • Previous Articles Next Articles

Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation

Ben Wang¹(), Si Li², Qing-Feng Wu², Wenhui Mu³()

1. Department of Obstetrics and Gynecology, Baoding No.2 Central Hospital, Baoding 072750, China
2. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
3. Inner Mongolia University, Hohhot 010021, China

Received:2023-02-07 Revised:2023-03-22 Online:2023-05-20 Published:2023-04-04
Contact: Mu Wenhui E-mail:wb111222@sina.com;wenhuimu1980@163.com
Supported by:
Technical Research Program of Baoding City No(2141ZF027);National Key Research & Development Program of China(2019YFA0801900);National Key Research & Development Program of China(2018YFA0801104);National Natural Science Foundation of China(32070972);National Natural Science Foundation of China(31771131);National Natural Science Foundation of China(31800860);National Natural Science Foundation of China(81891002);National Natural Science Foundation of China(31921002);Strategic Priority Research Program of Chinese Academy of Sciences(XDB32020000);Hundred-Talent Program (Chinese Academy of Sciences)(Z181100001518001)

Abstract

Abstract:

Hypothalamic median eminence (ME) is a potential niche for neurons and oligodendrocytes, and trophic factors may regulate hypothalamic function by inducing cellular changes in the ME region. To determine whether diet-induced plasticity exists in hypothalamic stem cells dormant under physiological conditions, we used a combination of a normal diet, a high-fat diet, and a ketogenic diet (a low-carb, high-fat diet) to compare the proliferation of tanycytes (TCs) and oligodendrocyte precursor cells (OPCs) in the ME area of mice under the different diets. The results showed that the ketogenic diet could induce and promote the proliferation of OPCs in the ME area, and blocking the fatty acid oxidation program could inhibit the proliferation of OPCs induced by a ketogenic diet. This study preliminarily revealed the diet-induced effect on OPCs in the ME region and provided enlightenment for further study on the function of OPCs in the ME region.

Key words: hypothalamus, median eminence, oligodendrocyte precursor cells, ketogenic diet

Ben Wang, Si Li, Qing-Feng Wu, Wenhui Mu. Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation[J]. Hereditas(Beijing), 2023, 45(5): 425-434.

Figures/Tables 4

References 23

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Ketogenic diet promotes the proliferation of oligodendrocyte precursor cells in ME region by activating fatty acid oxidation

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