Abstract: To investigate the distribution and significance of a coding single nucleotide polymorphism(cSNP)of the novel NIDDM candidate gene,KCNA7 in the population of Northeast China,97 patients with NIDDM and 141 controls were tested.Genotypes of KCNA7 gene T418M（C/T）were performed by PCR-RFLP,and SSCP was used to detect other unknown variations near the C/T site of KCNA7 gene.As a result,no significant difference was observed in the distribution of genotypes of T418M（C/T）between NIDDM and control group.Clinical biochemical examinations showed no significant difference between genotypes in both INDDM and control group,and no other SNPs were found near the C/T site of KCNA7 gene.This study demonstrates the frequency of this cSNP complies well with the Hardy-Weinberg equilibrium in normal group,T418M（C/T）is only a polymorphic maker of KCNA7 gene,and the possibility of association between NIDDM and KCNA7 can not be excluded.