动物早期胚胎发育中染色质结构的继承和重编程
The inheritance and reprogramming of chromatin structure in early animal embryos
动物早期胚胎发育中染色质结构的继承和重编程 |
| 柯玉文,刘江 |
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The inheritance and reprogramming of chromatin structure in early animal embryos |
| Ke Yuwen,Liu Jiang |
| 图1 染色质开放性在小鼠和人早期胚胎发育的重编程 左侧部分显示DNase-seq方法检测到小鼠和人早期胚胎中的染色质开放状态模式,DNase-seq信号在ZGA前基本检测不到;右侧部分显示ATAC-seq方法检测到小鼠和人早期胚胎中的染色质开放状态模式,ATAC-seq信号在ZGA前的染色质上广泛存在。在ZGA后,DNase-seq与ATAC-seq得到的染色质开放性图谱比较类似。P代表启动子(promoter);E代表增强子(enhancer);TSS代表转录起始位点(transcription start site);TES代表转录终止位点(transcription end site)。 |
| Fig. 1 The reprogramming of chromatin accessibility during early embryo development in the mouse and human |
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