稀有变异遗传关联性研究中常用负担检验方法比较

林欣琪,梁融,张俊国,皮路程,陈思东,刘丽,郜艳晖

Comparison of common burden tests for genetic association studies of rare variants

Lin Xinqi,Liang Rong,Zhang Junguo,Pi Lucheng,Chen Sidong,Liu Li,Gao Yanhui

Table 4 Results of power in various methods under the less MAF while more effects with associated rare variants

$n_{1}=n_{0}$ 方法 非关联变异数=0 非关联变异数=4 非关联变异数=8 非关联变异数=16 $\rho=0$ $\rho=0.5$ $\rho=0.9$ $\rho=0$ $\rho=0.5$ $\rho=0.9$ $\rho=0$ $\rho=0.5$ $\rho=0.9$ $\rho=0$ $\rho=0.5$ $\rho=0.9$ 250 CMC 0.596 0.695 0.998 0.215 0.548 0.979 0.217 0.415 0.949 0.189 0.314 0.905 WST 0.605 0.803 0.999 0.276 0.508 0.942 0.181 0.367 0.898 0.156 0.296 0.837 SUM 0.620 0.914 1.000 0.239 0.817 1.000 0.154 0.729 0.999 0.112 0.714 0.999 SSU 0.289 0.828 1.000 0.085 0.658 1.000 0.075 0.591 0.996 0.066 0.610 0.999 SSUw 0.297 0.850 1.000 0.225 0.841 1.000 0.185 0.778 1.000 0.165 0.761 1.000 aSUM 0.487 0.858 1.000 0.232 0.769 0.999 0.151 0.667 0.999 0.105 0.639 0.999 500 CMC 0.540 0.683 1.000 0.190 0.553 0.995 0.230 0.414 0.988 0.169 0.343 0.964 WST 0.545 0.766 0.999 0.239 0.427 0.916 0.199 0.310 0.874 0.157 0.250 0.799 SUM 0.560 0.890 1.000 0.211 0.764 1.000 0.158 0.675 1.000 0.107 0.637 0.998 SSU 0.272 0.783 1.000 0.056 0.550 1.000 0.072 0.519 1.000 0.054 0.539 0.997 SSUw 0.272 0.813 1.000 0.212 0.803 1.000 0.195 0.738 1.000 0.150 0.707 1.000 aSUM 0.455 0.831 1.000 0.211 0.692 1.000 0.146 0.596 1.000 0.109 0.581 0.999 1000 CMC 0.506 0.619 0.997 0.181 0.482 0.991 0.212 0.303 0.980 0.183 0.374 0.946 WST 0.511 0.700 0.998 0.232 0.259 0.841 0.171 0.287 0.767 0.146 0.227 0.699 SUM 0.542 0.837 1.000 0.200 0.675 0.999 0.144 0.645 0.996 0.096 0.585 0.998 SSU 0.230 0.724 1.000 0.065 0.470 0.999 0.057 0.430 0.995 0.069 0.467 0.996 SSUw 0.259 0.767 1.000 0.201 0.727 1.000 0.182 0.719 1.000 0.161 0.654 0.999 aSUM 0.428 0.778 1.000 0.190 0.611 1.000 0.127 0.563 0.997 0.109 0.508 0.997