唐氏综合征小鼠模型的遗传背景和应用

孟晓伟,汪洁,马晴雯

The genetic background and application of Down syndrome mouse models

Meng Xiaowei,Wang Jie,Ma Qingwen

表2 Tc1-Hsa21中重复和删除的基因

Table 2 The duplicated and deleted genes in Tc1-Hsa21

删除/重复基因 基因名称 完全删除基因 BTG3, C21orf91, NCRNA00157, CHODL, C21orf45, MRAP, URB1, SNORA80, C21orf119, C21orf63, TCP10L, C21orf59, SYNJ1, GCFC1, C21orf49, C21orf62, OLIG2, OLIG1, C21orf54, IFNAR2, IL10RB, IFNAR1, IFNGR2, TMEM50B, DNAJC28, GART, SON, DONSON, CRYZL1, ITSN1, ATP5O, MRPS6, SLC5A3, C21orf82, KCNE2, FAM165B, KCNE1, RCAN1, CLIC6, NCRNA00160, SLC19A1 部分删除基因 TMPRSS15, RUNX1, COL18A1, PCBP3 完全重复基因 BAGE5, BAGE4, BAGE2, BAGE3, BAGE, RBM11, ABCC13, HSPA13, SAMSN1, NRIP1, USP25, S100B, PRMT2, C21orf131 部分重复基因 LIPI, C21orf34, DIP2A, NCAM2