MicroRNA调控耳蜗毛细胞发育的分子机制

饶琳, 孟飞龙, 房冉, 蔡晨依, 赵小立

Molecular mechanism of microRNA in regulating cochlear hair cell development

Rao Lin, Meng Feilong, Fang Ran, Cai Chenyi, Zhao Xiaoli

表1 miRNA在耳蜗中的靶基因

Table 1 Target gene of miRNA in inner ear cochlea

miRNA 靶基因 参考文献 miR-9 COL9A1 [72] miR-29 SIRT1 [80] miR-34a SIRT1、bcl-2和E2F-3 [80] miR-96 TRK和EGFR [52] Slc26a5、Ocm、Gfi1、Ptprq和Pitpnm1 [59] miR-96/-182 CLIC5 [73] miR-124 Sfrp4和Sfrp5 [74] miR-135b PSIP1-P75 [82] miR-140 NR2F1和Klf9 [83] miR-182 Sox2和Tbx1 [84] miR-183 Taok1和ltgA3 [70] miR-194 Fgf4和RhoB [76] miR-200 Zeb1和Zeb2 [85] miR-204 TMPRSS3 [86] miR-224 Ptx3 [87] miR-376 PRPS1 [78]