肌动蛋白细胞骨架在小鼠第二生心区祖细胞部署发育中的作用

刘钟颖,黄霞,李紫怡,杨子豪,袁白银

The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells

Liu Zhongying,Huang Xia,Li Ziyi,Yang Zihao,Yuan Baiyin

表1 横纹肌中重要的肌动蛋白动态调控因子

Table 1 Vital regulators of actin dynamics in striated muscle

调控因子 功能 参考文献 CapZ 调节细肌丝的组装及结构 [81,82] Tropomodulin 抑制负极端actin dynamics,细肌丝组装及长度调节等 [76,83~86] Nubulin 稳定F-actin,调节细肌丝长度及肌小节结构等 [87~90] Tropomyosin 稳定F-actin,调控肌小节细肌丝组装 [91,92] ADF/Cofilin 促进actin dynamics,调控细肌丝的正确组装 [78,93,94] WDR1 促进actin dynamics,调节细肌丝的正确组装 [95,96,101,102] Leiomodin 促进F-actin聚合,调节细肌丝组装及长度 [86,97~99] FHOD3 促进actin聚合,调节肌小节组装 [100]