PRC1.6复合体表观遗传调控生殖谱系特异性基因的时空表达

孙晓伟,李宏阳,王健,程博

Controlling the spatiotemporal expression of germ line specific genes by PRC1.6 complex

Sun Xiaowei,Li Hongyang,Wang Jian,Cheng Bo

表1 PRC1.6复合体的发现及组分

Table 1 Discovery and identification of the components of PRC1.6 complex

复合体命名 组分 细胞系 文献 E2F6.com E2F6、PCGF6、RING1B、MAX、MGA、L3MBTL2、HP1γ、DP-1/2、YAF2、G9a和Eu-HMTase1(GLP) HeLa [19] PRC1-like 4 (PRC1L4) E2F6、PCGF6、RING1B/RING1A、L3MBTL2、HP1γ和MBLR HEK293T [20] PRC1.6 E2F6、PCGF6、RING1B、MAX、MGA、L3MBTL2、HP1γ、DP-1/2、HDAC1/2、RYBP/YAF2和WDR5 293TREx [21] PCGF6-PRC1 PCGF6、RING1B/RING1A、MGA、L3MBTL2、HP1γ、HP1β、DP-1和RYBP/YAF2 mESCs [22]