连续性纯合片段在畜禽基因组研究中的应用

刘刚,孙飞舟,朱芳贤,冯海永,韩旭

Runs of homozygosity and its application on livestock genome study

Liu Gang,Sun Feizhou,Zhu Fangxian,Feng Haiyong,Han Xu

表2 畜禽群体中鉴定ROH信息以及基于系谱信息和基因组信息近交系数的相关系数统计表

Table 2 Studies of ROH and correlations between the inbreeding from pedigree data and from genome data through ROH in livestock and poultry species

物种 品种/群体 数量 ROH平均 数量 ROH平均 长度(Mb) 相关系数 参考文献 FPED①, FROH FPED, FROH>1 Mb FPED, FROH>2 Mb FPED, FROH>4 Mb FPED, FROH>8 Mb FPED, FROH>16 Mb 牛 (Bos taurus) Austrian Simmental 500 - - - 0.64 0.67 0.68 0.68 0.63 [4] Multiple breeds 891 - 0.30~5.09② 0.71 - - - - - [10] Brown Swiss 304 98.9 1.30 - 0.66 0.67 - 0.60 0.50 [5] Fleckvieh 502 94.5 0.44 0.66 0.69 0.70 0.64 Nowegian Red 498 80.0 0.51 0.61 0.61 0.62 0.53 Tyrol Grey 117 72.3 1.88 0.71 0.72 0.71 0.70 物种 品种/群体 数量 ROH平均 数量 ROH平均 长度(Mb) 相关系数 参考文献 FPED①, FROH FPED, FROH>1 Mb FPED, FROH>2 Mb FPED, FROH>4 Mb FPED, FROH>8 Mb FPED, FROH>16 Mb 牛 (Bos taurus) Italian Holstein 2093 81.7 3.6 - 0.70 - 0.69 0.65 0.56 [20] Italian Brown 749 94.6 3.9 0.66 0.66 0.65 0.58 Italian Simmental 479 94.3 2.2 0.66 0.74 0.76 0.71 Jersey 1602 - - 0.70③/0.71④ - - - - - [57] Cinisara 71 9.38 13.57 0.45 - - - - - [82] Modicana 72 110.3 12.31 0.27 Reggiana 168 10.42 10.16 0.31 Italian Holstein 96 7.15 11.78 0.44 Holstein 2107 21.2 8.02 0.73 - - - - - [83] Maasai - 103 17.46 0.90 - - - - - [84] Tarime 56 13.12 0.75 Sukuma 36 10.65 0.61 Boran 99 9.48 0.56 Friesian 155 9.68 0.54 Brown Swiss 281 21.0 2264 0.45 - - - - - [23] Braunvieh 3386 18.6 184.6 Origianl Braunvieh 167 8.4 73.7 Holstein 2568 14.2 145.2 Red Holstein 1960 11.2 112.1 Swiss Fleckvieh 547 7.1 75.6 Simmental 248 10.9 96.6 Eringer 36 8.5 66.2 Evolèner 21 15.5 185.7 猪 (Sus scrofa) Iberian 64 - - - 0.77 - - 0.81 - [68] Yorkshire 2358 - - 0.69 - - - - - [23] Guadyerbas 109 - - 0.63 -0.24 - - 0.60 - [24] Landrace 1178 52.7 252.9 0.24 - - - - - [69] Large White 1200 61.4 280.1 0.015 Duroc 1066 16.72 6.75 0.31 - - - - - [70] Landrace 768 23.19 11.27 0.32 Yrokshire 1111 25.88 11.99 0.53 Crossbred 112 8.25 2.6 0.00 马 (Equus caballus) Sorraia 2⑤ 4175⑥ 0.19 - - - - - - [29] Dülmen Horse 1⑤ 2804⑥ 0.14 Arabian 1⑤ 3581⑥ 0.15 Saxon-Thuringian 1⑤ 3138⑥ 0.15 Thoroughbred 1⑤ 4595⑥ 0.20 Hanoverian 4⑤ 311⑥ 0.14 物种 品种/群体 数量 ROH平均 数量 ROH平均 长度(Mb) 相关系数 参考文献 FPED①, FROH FPED, FROH>1 Mb FPED, FROH>2 Mb FPED, FROH>4 Mb FPED, FROH>8 Mb FPED, FROH>16 Mb 绵羊 (Ovis aries) Belclare 304 39.94~ 92.61⑦ 0.83-3.7 - 0.76 - 0.75⑧ 0.71⑨ - [34] Suffolk 53 0.54 0.55⑧ 0.58⑨ Texel 248 0.52 0.47⑧ 0.41⑨ Vendeen 238 0.15 0.15⑧ 0.12⑨ 山羊 (Capra hircus) Alpine 403 15.6 0.45 0.372 - - - - - [77] Boer(Ausralia) 61 23.6 0.48 Boer(Canada) 67 31.5 0.42 Cashmere 48 8.0 0.59 LaMancha 81 19.4 0.47 Nubian 54 31.2 0.43 Rangeland 66 5.2 0.38 Saanen 318 16.7 0.45 Toggenb 53 24.1 0.46