MEK抑制剂PD0325901显著提高猪胎儿成纤维细胞ssODN介导的HDR效率

欧浩,李国玲,王豪强,黄广燕,蔡更元,李紫聪,吴珍芳,张献伟

MEK inhibitor PD0325901 significantly boosts ssODN-mediated HDR efficiency in porcine fetal fibroblasts

Ou Hao,Li Guoling,Wang Haoqiang,Huang Guangyan,Cai Gengyuan,Li Zicong,Wu Zhenfang,Zhang Xianwei

图2 PD0325901对DNA修复因子表达水平的影响 XRCC5、XRCC6、LIG4和PNKP为NHEJ相关修复基因;Rad50、Rad51、Rad52和BRCA1为HDR相关修复基因。 * P<0.05,表示差异显著,** P<0.01表示差异极显著。

Fig. 2 The mRNA expression levels of DNA repair factors after treatment with PD0325901