Bmal1对小鼠胚胎期皮层神经元放射状迁移和轴突投射的影响
The role of Bmal1 in neuronal radial migration and axonal projection of the embryonic mouse cerebral cortex
Bmal1对小鼠胚胎期皮层神经元放射状迁移和轴突投射的影响 |
| 李芳,黄青芸,刘斯佳,郭忠信,熊欣欣,桂林,束会娟,黄绍明,谭国鹤,刘媛媛 |
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The role of Bmal1 in neuronal radial migration and axonal projection of the embryonic mouse cerebral cortex |
| Li Fang,Huang Qingyun,Liu Sijia,Guo Zhongxin,Xiong Xinxin,Gui Lin,Shu Huijuan,Huang Shaoming,Tan Guohe,Liu Yuanyuan |
| 图3 Bmal1基因表达下调对皮层神经元放射状迁移的影响 A：观察子宫内胚胎电转实验具体皮层电转位置。B：子宫内胚胎电转实验观察敲减Bmal1对E18.5小鼠神经元迁移的影响。切片用Hoechst 33324(蓝色)染色,标记相应皮层;CP：皮质板区;IZ：中间区;VZ：脑室;SVZ：脑室下区;标尺=125 μm。C：每个区域中 GFP 阳性细胞所占总阳性细胞百分比统计图。结果以平均值±S.E.M表示;每个发育阶段收集3只小鼠脑片;*P<0.05表示与Bmal1-shRNA-Scr组相比有统计学差异,**P<0.01表示与Bmal1-shRNA-Scr组相比统计学差异显著。 |
| Fig. 3 Effect of down-regulation of Bmal1 gene expression on radial migration of cortical neurons |
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