MKL1基因多态性与高原环境适应性的遗传关联研究
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张晴,平杰,张昊翔,康波,李元丰,周钢桥
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Genetic association of MKL1 gene polymorphisms with the high-altitude adaptation
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Zhang Qing,Ping Jie,Zhang Haoxiang,Kang Bo, ,Zhou Gangqiao
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| 表3 在藏族和千人基因组计划的5个人群中rs59098711位点的基因型和等位基因型的频率分布 |
| Table 3 Distributions of the genotypes and alleles frequencies of rs59098711 in Tibetans and five populations from 1000 Genomes Project |
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| 基因型 | 等位基因型 | | CC | TC | TT | C | T | | 藏族[例(%)] | 237(39.83) | 253(42.52) | 105(17.65) | 727(61.09) | 463(38.91) | | 东亚[例(%)] | 48(9.52) | 229(45.44) | 227(45.04) | 325(32.24) | 683(67.76) | | 南亚[例(%)] | 36(7.36) | 177(36.20) | 276(56.44) | 249(25.46) | 729(74.54) | | 欧洲[例(%)] | 24(4.77) | 151(30.02) | 328(65.21) | 199(19.78) | 807(80.22) | | 美洲[例(%)] | 6(1.73) | 74(21.32) | 267(76.95) | 86(12.39) | 608(87.61) | | 非洲[例(%)] | 46(6.96) | 282(42.66) | 333(50.38) | 374(28.29) | 948(71.71) | | 藏族vs.东亚 | | | | | | | OR(95% CI) | | 4.47(3.16~6.32) | 10.67(7.42~15.36) | | 3.30(2.77~3.93) | | χ2 | | 71.69 | 162.76 | | 180.87 | | P | | 2.52×10-17 | 2.83×10-37 | | 3.12×10-41 | | 藏族vs.南亚 | | | | | | | OR(95% CI) | | 4.60(3.13~6.77) | 17.30(11.89~25.19) | | 4.60(3.83~5.51) | | χ2 | | 60.57 | 221.46 | | 273.93 | | P | | 7.11×10-15 | 4.34×10-50 | | 1.58×10-61 | | 藏族vs.欧洲 | | | | | | | OR(95% CI) | | 5.89(3.81~9.12) | 30.84(20.73~45.90) | | 6.37(5.29~7.67) | | χ2 | | 63.5 | 285.93 | | 379.81 | | P | | 1.61×10-15 | 3.82×10-64 | | 1.37×10-84 | | 藏族vs.美洲 | | | | | | | OR(95% CI) | | 11.55(5.66~23.56) | 100.44(58.72~171.82) | | 11.10(8.82~13.97) | | χ2 | | 45.31 | 283.20 | | 421.83 | | P | | 1.68×10-11 | 1.51×10-63 | | 9.75×10-94 | | 藏族vs.非洲 | | | | | | | OR(95% CI) | | 5.74(4.08~8.08) | 16.34(11.51~23.20) | | 3.98(3.38~4.69) | | χ2 | | 100.90 | 243.95 | | 272.37 | | P | | 9.67×10-24 | 5.41×10-55 | | 3.45×10-61 |
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