HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析

卢涣滋,王迪侃,王智

Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load

Lu Huanzi,Wang Dikan,Wang Zhi

表4 HPV+口咽癌中频率最高的新抗原及其突变位点和MHC-Ⅰ限制性表位肽序列

Table 4 The most frequent neoantigens in HPV+ oropharyngeal cancer patients and their mutation sites and MHC-Ⅰ restricted epitope sequences

基因 突变位点和MHC-Ⅰ限制性表位肽序列 新抗原频数 突变位点 氨基酸改变 MHC-Ⅰ抗原表位肽 表位肽频率（%） PIK3CA 3 G1633A E545K STRDPLSEITK 66.7 G1624A E542K STRDPLSKI 33.3 TTN 3 G32095A E10699K EEYKEREYERY 33.3 C90043G L30015V KEVDLCEKVSL 33.3 C89771G S29924C IVCDNFFTV 33.3 FBXW7 2 C1513G R505G HVAAVGCVQY 100 FGFR3 2 C2005G R669G ALFDGVYT 100 DIDO1 2 G3061A D1021N SSSPNPRYL 50 G2959A D987N ASRPNSTHM 50