HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析

卢涣滋,王迪侃,王智

Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load

Lu Huanzi,Wang Dikan,Wang Zhi

表5 HPV-口咽癌中频率最高的新抗原及其突变位点和MHC-Ⅰ限制性表位肽序列

Table 5 The most frequent neoantigens in HPV- oropharyngeal cancer patients and their mutation sites and MHC-Ⅰ restricted epitope sequences

基因 HPV-口咽癌新抗原突变位点及其MHC-Ⅰ表位肽序列 新抗原频数 突变位点 氨基酸改变 MHC-Ⅰ抗原表位肽 口咽癌中表位肽频率（%） PIK3CA 8 G1624A E542K STRDPLSKI 50 G1633A E545K STRDPLSEITK 25 G263A R88Q EEFFDETRQL 12.5 A3140G H1047R ARHGGWTTKM 12.5 TP53 5 G314T G105V YQVSYGFRL 40 C742T R248W GGMNWRPIL 20 C451A P151S STTPPGTRV 20 A578T H193L GLAPPQLLIR 20 DMD 4 G9436A D3146N QPMNILQII 25 A2306G E769G NAIERGKAEK 25 G2155A E719K ITVDSKIRK 25 G7244A R2415H SEWKAVNHL 25 MUC16 4 C26954T A8985V TTIPVSSEITR 25 C21370T L7124F SPFPVTSL 25 C35552A S11851Y VSAKTAPLY 25 G4225C E1409Q AEKSSGFQT 25 TTN 3 C85880T S28627L SIEKRETL 33.3 C87575T T29192I VTDISKTTV 33.3 G20164T D6722Y SYRAVPPSF 33.3