内侧前额叶皮质DNA甲基化调控大鼠酒精相关行为

崔亨贞, 孙蜜烛, 王润芝, 李辰雨, 黄予暄, 黄秋菊, 乔晓孟

DNA methylation in the medial prefrontal cortex regulates alcohol-related behavior in rats

Cui Hengzhen, Sun Mizhu, Wang Runzhi, Li Chenyu, Huang Yuxuan, Huang Qiuju, Qiao Xiaomeng

图5 慢性酒精暴露后大鼠mPFC内DNMT1、DNMT3A、DNMT3B和MeCP2蛋白及mRNA表达改变 A：慢性酒精暴露后大鼠mPFC内DNMT1、DNMT3A、DNMT3B和MeCP2蛋白条带;B：慢性酒精暴露后大鼠mPFC内DNMT1、DNMT3A、DNMT3B和MeCP2蛋白表达;C：慢性酒精暴露后大鼠mPFC内DNMT1、DNMT3A、DNMT3B和MeCP2的mRNA表达。与饮水组比较,***: P<0.001表示差异显著,****: P< 0.0001表示差异极显著。

Fig. 5 Changes in DNMT1, DNMT3A, DNMT3B and MeCP2 protein and mRNA expression in rats mPFC tissue after chronic alcohol exposure