2019新型冠状病毒信息库

赵文明, 宋述慧, 陈梅丽, 邹东, 马利娜, 马英克, 李茹姣, 郝丽丽, 李翠萍, 田东梅, 唐碧霞, 王彦青, 朱军伟, 陈焕新, 章张, 薛勇彪, 鲍一明

The 2019 novel coronavirus resource

Zhao Wenming, Song Shuhui, Chen Meili, Zou Dong, Ma Lina, Ma Yingke, Li Rujiao, Hao Lili, Li Cuiping, Tian Dongmei, Tang Bixia, Wang Yanqing, Zhu Junwei, Chen Huanxin, Zhang Zhang, Xue Yongbiao, Bao Yiming

附表2 2019-nCoV基因组序列变异注释信息

Table S2 Genome variants and annotations

基因组位置 基因/区域名称 变异病毒株数 碱基变化及病毒株数 变异注释类型 蛋白名称.位置.氨基酸变化 基因名.CDS位置.序列变化 效应类型 2019-nCoV_16 5'UTR 1 C->T:1 intergenic_variant - - MODIFIER 2019-nCoV_31 5'UTR 1 A->G:1 intergenic_variant - - MODIFIER 2019-nCoV_104 5'UTR 1 T->A:1 intergenic_variant - - MODIFIER 2019-nCoV_111 5'UTR 1 T->C:1 intergenic_variant - - MODIFIER 2019-nCoV_112 5'UTR 1 T->G:1 intergenic_variant - - MODIFIER 2019-nCoV_119 5'UTR 1 C->G:1 intergenic_variant - - MODIFIER 2019-nCoV_120 5'UTR 1 T->C:1 intergenic_variant - - MODIFIER 2019-nCoV_124 5'UTR 1 G->A:1 intergenic_variant - - MODIFIER 2019-nCoV_241 5'UTR 1 C->T:1 upstream_gene_variant QHD43415.1 gene-orf1ab MODIFIER;DISTANCE=25 2019-nCoV_358 gene-orf1ab 1 TGGAGACTCCGTGGAGGAGGTCTTA->T:1 inframe_deletion QHD43415.1:p.32-39GDSVEEVL>- gene-orf1ab:c.94-117GGAGACTCCGTGGAGGAGGTCTTA>- MODERATE 2019-nCoV_490 gene-orf1ab 1 T->W:1 coding_sequence_variant QHD43415.1:p.75- gene-orf1ab:c.225gaT>gaW MODIFIER 2019-nCoV_583 gene-orf1ab 1 C->T:1 synonymous_variant QHD43415.1:p.106V gene-orf1ab:c.318gtC>gtT LOW 2019-nCoV_709 gene-orf1ab 1 G->A:1 synonymous_variant QHD43415.1:p.148E gene-orf1ab:c.444gaG>gaA LOW 2019-nCoV_1548 gene-orf1ab 1 G->A:1 missense_variant QHD43415.1:p.428S>N gene-orf1ab:c.1283aGc>aAc MODERATE 2019-nCoV_1912 gene-orf1ab 1 C->T:1 synonymous_variant QHD43415.1:p.549S gene-orf1ab:c.1647tcC>tcT LOW 2019-nCoV_3037 gene-orf1ab 1 C->T:1 synonymous_variant QHD43415.1:p.924F gene-orf1ab:c.2772ttC>ttT LOW 2019-nCoV_3177 gene-orf1ab 1 C->Y:1 coding_sequence_variant QHD43415.1:p.971- gene-orf1ab:c.2912cCt>cYt MODIFIER 2019-nCoV_3778 gene-orf1ab 1 A->G:1 synonymous_variant QHD43415.1:p.1171T gene-orf1ab:c.3513acA>acG LOW 2019-nCoV_4402 gene-orf1ab 1 T->C:1 synonymous_variant QHD43415.1:p.1379L gene-orf1ab:c.4137ctT>ctC LOW 2019-nCoV_5062 gene-orf1ab 1 G->T:1 missense_variant QHD43415.1:p.1599L>F gene-orf1ab:c.4797ttG>ttT MODERATE 2019-nCoV_6846 gene-orf1ab 1 T->C:1 missense_variant QHD43415.1:p.2194M>T gene-orf1ab:c.6581aTg>aCg MODERATE 2019-nCoV_6968 gene-orf1ab 1 C->A:1 missense_variant QHD43415.1:p.2235L>I gene-orf1ab:c.6703Cta>Ata MODERATE 2019-nCoV_6996 gene-orf1ab 1 T->C:1 missense_variant QHD43415.1:p.2244I>T gene-orf1ab:c.6731aTc>aCc MODERATE 2019-nCoV_7016 gene-orf1ab 1 G->A:1 missense_variant QHD43415.1:p.2251G>S gene-orf1ab:c.6751Ggt>Agt MODERATE 2019-nCoV_7866 gene-orf1ab 1 G->T:1 missense_variant QHD43415.1:p.2534G>V gene-orf1ab:c.7601gGt>gTt MODERATE 2019-nCoV_8001 gene-orf1ab 1 A->C:1 missense_variant QHD43415.1:p.2579D>A gene-orf1ab:c.7736gAt>gCt MODERATE 2019-nCoV_8388 gene-orf1ab 1 A->G:1 missense_variant QHD43415.1:p.2708N>S gene-orf1ab:c.8123aAc>aGc MODERATE 2019-nCoV_8782 gene-orf1ab 16 C->T:15;C->Y:1 synonymous_variant;coding_sequence_variant QHD43415.1:p.2839S;QHD43415.1:p.2839- gene-orf1ab:c.8517agC>agT;gene-orf1ab:c.8517agC>agY LOW;MODIFIER 2019-nCoV_8987 gene-orf1ab 1 T->A:1 missense_variant QHD43415.1:p.2908F>I gene-orf1ab:c.8722Ttt>Att MODERATE 2019-nCoV_9534 gene-orf1ab 1 C->T:1 missense_variant QHD43415.1:p.3090T>I gene-orf1ab:c.9269aCt>aTt MODERATE 2019-nCoV_9561 gene-orf1ab 1 C->T:1 missense_variant QHD43415.1:p.3099S>L gene-orf1ab:c.9296tCa>tTa MODERATE 2019-nCoV_11083 gene-orf1ab 1 G->T:1 missense_variant QHD43415.1:p.3606L>F gene-orf1ab:c.10818ttG>ttT MODERATE 2019-nCoV_11707 gene-orf1ab 1 A->G:1 synonymous_variant QHD43415.1:p.3814L gene-orf1ab:c.11442ttA>ttG LOW 2019-nCoV_11764 gene-orf1ab 1 T->A:1 missense_variant QHD43415.1:p.3833N>K gene-orf1ab:c.11499aaT>aaA MODERATE 2019-nCoV_15324 gene-orf1ab 1 C->T:1 synonymous_variant QHD43415.1:p.5020N gene-orf1ab:c.15060aaC>aaT LOW 2019-nCoV_15607 gene-orf1ab 1 T->C:1 synonymous_variant QHD43415.1:p.5115L gene-orf1ab:c.15343Tta>Cta LOW 2019-nCoV_16188 gene-orf1ab 1 G->T:1 missense_variant QHD43415.1:p.5308W>C gene-orf1ab:c.15924tgG>tgT MODERATE 2019-nCoV_17000 gene-orf1ab 1 C->T:1 missense_variant QHD43415.1:p.5579T>I gene-orf1ab:c.16736aCa>aTa MODERATE 2019-nCoV_17373 gene-orf1ab 2 C->T:2 synonymous_variant QHD43415.1:p.5703A gene-orf1ab:c.17109gcC>gcT LOW 2019-nCoV_18060 gene-orf1ab 3 C->T:3 synonymous_variant QHD43415.1:p.5932L gene-orf1ab:c.17796ctC>ctT LOW 2019-nCoV_18488 gene-orf1ab 2 T->C:2 missense_variant QHD43415.1:p.6075I>T gene-orf1ab:c.18224aTa>aCa MODERATE 2019-nCoV_18512 gene-orf1ab 1 C->T:1 missense_variant QHD43415.1:p.6083P>L gene-orf1ab:c.18248cCt>cTt MODERATE 2019-nCoV_19065 gene-orf1ab 1 T->C:1 synonymous_variant QHD43415.1:p.6267P gene-orf1ab:c.18801ccT>ccC LOW 2019-nCoV_19959 gene-orf1ab 1 A->C:1 missense_variant QHD43415.1:p.6565E>D gene-orf1ab:c.19695gaA>gaC MODERATE 2019-nCoV_20670 gene-orf1ab 2 G->A:2 synonymous_variant QHD43415.1:p.6802A gene-orf1ab:c.20406gcG>gcA LOW 2019-nCoV_20679 gene-orf1ab 2 G->A:2 synonymous_variant QHD43415.1:p.6805P gene-orf1ab:c.20415ccG>ccA LOW 2019-nCoV_21137 gene-orf1ab 1 A->G:1 missense_variant QHD43415.1:p.6958K>R gene-orf1ab:c.20873aAg>aGg MODERATE 2019-nCoV_21316 gene-orf1ab 1 G->A:1 missense_variant QHD43415.1:p.7018D>N gene-orf1ab:c.21052Gat>Aat MODERATE 2019-nCoV_21656 gene-S 1 T->A:1 missense_variant QHD43416.1:p.32F>I gene-S:c.94Ttc>Atc MODERATE 2019-nCoV_21707 gene-S 3 C->T:3 missense_variant QHD43416.1:p.49H>Y gene-S:c.145Cat>Tat MODERATE 2019-nCoV_22303 gene-S 1 T->G:1 missense_variant QHD43416.1:p.247S>R gene-S:c.741agT>agG MODERATE 2019-nCoV_22586 gene-S 1 T->Y:1 coding_sequence_variant QHD43416.1:p.342- gene-S:c.1024Ttt>Ytt MODIFIER 2019-nCoV_22622 gene-S 1 A->G:1 missense_variant QHD43416.1:p.354N>D gene-S:c.1060Aac>Gac MODERATE 2019-nCoV_22652 gene-S 1 G->T:1 missense_variant QHD43416.1:p.364D>Y gene-S:c.1090Gat>Tat MODERATE 2019-nCoV_22661 gene-S 2 G->T:2 missense_variant QHD43416.1:p.367V>F gene-S:c.1099Gtc>Ttc MODERATE 2019-nCoV_23403 gene-S 1 A->G:1 missense_variant QHD43416.1:p.614D>G gene-S:c.1841gAt>gGt MODERATE 2019-nCoV_23569 gene-S 2 T->C:2 synonymous_variant QHD43416.1:p.669G gene-S:c.2007ggT>ggC LOW 2019-nCoV_23605 gene-S 2 T->G:2 synonymous_variant QHD43416.1:p.681P gene-S:c.2043ccT>ccG LOW 2019-nCoV_24034 gene-S 2 C->T:1;C->Y:1 synonymous_variant;coding_sequence_variant QHD43416.1:p.824N;QHD43416.1:p.824- gene-S:c.2472aaC>aaT;gene-S:c.2472aaC>aaY LOW;MODIFIER 2019-nCoV_24325 gene-S 2 A->G:2 synonymous_variant QHD43416.1:p.921K gene-S:c.2763aaA>aaG LOW 2019-nCoV_25060 gene-S 1 A->G:1 synonymous_variant QHD43416.1:p.1166L gene-S:c.3498ttA>ttG LOW 2019-nCoV_25645 gene-ORF3a 1 T->C:1 synonymous_variant QHD43417.1:p.85L gene-ORF3a:c.253Ttg>Ctg LOW 2019-nCoV_25964 gene-ORF3a 1 A->G:1 missense_variant QHD43417.1:p.191E>G gene-ORF3a:c.572gAa>gGa MODERATE 2019-nCoV_26144 gene-ORF3a 5 G->T:5 missense_variant QHD43417.1:p.251G>V gene-ORF3a:c.752gGt>gTt MODERATE 2019-nCoV_26729 gene-M 2 T->C:1;T->Y:1 synonymous_variant;coding_sequence_variant QHD43419.1:p.69A;QHD43419.1:p.69- gene-M:c.207gcT>gcC;gene-M:c.207gcT>gcY LOW;MODIFIER 2019-nCoV_27493 gene-ORF7a 2 C->T:2 missense_variant QHD43421.1:p.34P>S gene-ORF7a:c.100Cct>Tct MODERATE 2019-nCoV_27577 gene-ORF7a 1 C->T:1 stop_gained QHD43421.1:p.62Q>* gene-ORF7a:c.184Caa>Taa HIGH 2019-nCoV_28077 gene-ORF8 2 G->S:1;G->C:1 coding_sequence_variant;missense_variant QHD43422.1:p.62-;QHD43422.1:p.62V>L gene-ORF8:c.184Gtg>Stg;gene-ORF8:c.184Gtg>Ctg MODIFIER;MODERATE 2019-nCoV_28144 gene-ORF8 16 T->C:15;T->Y:1 missense_variant;coding_sequence_variant QHD43422.1:p.84L>S;QHD43422.1:p.84- gene-ORF8:c.251tTa>tCa;gene-ORF8:c.251tTa>tYa MODERATE;MODIFIER 2019-nCoV_28253 gene-ORF8 2 C->T:2 synonymous_variant QHD43422.1:p.120F gene-ORF8:c.360ttC>ttT LOW 2019-nCoV_28291 gene-N 1 C->T:1 synonymous_variant QHD43423.2:p.6P gene-N:c.18ccC>ccT LOW 2019-nCoV_28716 gene-N 1 C->T:1 missense_variant QHD43423.2:p.148T>I gene-N:c.443aCc>aTc MODERATE 2019-nCoV_28792 gene-N 1 A->T:1 synonymous_variant QHD43423.2:p.173A gene-N:c.519gcA>gcT LOW 2019-nCoV_28854 gene-N 3 C->T:2;C->Y:1 missense_variant;coding_sequence_variant QHD43423.2:p.194S>L;QHD43423.2:p.194- gene-N:c.581tCa>tTa;gene-N:c.581tCa>tYa MODERATE;MODIFIER 2019-nCoV_29095 gene-N 7 C->T:7 synonymous_variant QHD43423.2:p.274F gene-N:c.822ttC>ttT LOW 2019-nCoV_29303 gene-N 1 C->T:1 missense_variant QHD43423.2:p.344P>S gene-N:c.1030Cca>Tca MODERATE 2019-nCoV_29596 gene-ORF10 1 A->G:1 missense_variant QHI42199.1:p.13I>M gene-ORF10:c.39atA>atG MODERATE 2019-nCoV_29749 3'UTR 1 ACGATCGAGTG->A:1 downstream_gene_variant QHI42199.1 gene-ORF10 MODIFIER;DISTANCE=76 2019-nCoV_29854 3'UTR 1 C->T:1 intergenic_variant - - MODIFIER 2019-nCoV_29856 3'UTR 1 T->A:1 intergenic_variant - - MODIFIER 2019-nCoV_29868 3'UTR 1 GA->G:1 intergenic_variant - - MODIFIER 2019-nCoV_29877 3'UTR 1 A->T:1 intergenic_variant - - MODIFIER