中国人群中抗结核药物引发肝损伤的易感基因标记研究

周晨希, 李沫, 怀聪, 贺林, 秦胜营

Study on hereditary susceptibility genetic markers to anti-tuberculosis drug induced liver injury in Chinese population

Zhou Chenxi, Li Mo, Huai Cong, He Lin, Qin Shengying

表2 与抗结核药物导致的肝损伤显著相关的SNP/SNV

Table 2 Significant SNP/SNVs associated with anti-tuberculosis drug induced liver injury

基因 编号 频数 REF/ALT 比值比(OR) 95%置信区间(95%CI) P值 结核病人 健康人 UGT1A4 rs2011404 6/74 23/55 0.1939 0.0740~0.5083 0.0004 CYP2D6 rs16947 64/12 70/2 6.5620 1.4140~30.4500 0.0069 CYP2S1 rs338599 71/9 56/18 0.3944 0.1646~0.9446 0.0330