中国人群中抗结核药物引发肝损伤的易感基因标记研究

周晨希, 李沫, 怀聪, 贺林, 秦胜营

Study on hereditary susceptibility genetic markers to anti-tuberculosis drug induced liver injury in Chinese population

Zhou Chenxi, Li Mo, Huai Cong, He Lin, Qin Shengying

表3 验证与抗结核药物导致肝损伤显著相关的SNP/SNV

Table 3 Validation of significant SNP/SNVs associated with anti-tuberculosis drug induced liver injury

基因 编号 等位基因 REF/ALT 等位基因频率 卡方(χ2) P值 结核病人 东亚健康人群数据库 UGT1A4 rs2011404 T/G 0.0750/0.9250 0.0258/0.9742 4.6809 0.0305 CYP2D6 rs16947 G/A 0.8421/0.1579 0.8601/0.1399 0.0698 0.7917 CYP2S1 rs338599 C/G 0.8875/0.1125 0.7897/0.2103 3.7978 0.0513