2型糖尿病易感基因SNP位点对生活方式干预降低血糖应答效果的修饰效应

王玉琢, 张一鸣, 董晓莲, 王学才, 朱建福, 王娜, 江峰, 陈跃, 姜庆五, 付朝伟

Modification effects of T2DM-susceptible SNPs on the reduction of blood glucose in response to lifestyle interventions

Wang Yuzhuo, Zhang Yiming, Dong Xiaolian, Wang Xuecai, Zhu Jianfu, Wang Na, Jiang Feng, Chen Yue, Jiang Qingwu, Fu Chaowei

附表1 rs9502570的不同基因型在干预组和对照组空腹血糖、糖化血红蛋白值前后差值对比(未调整协变量)

Supplementary Table 1 Comparisons of the difference in the reduction of fasting blood glucose and HbA1c between the intervention and control groups by different genotype of rs9502570 without the adjustment of possible covariates

指标 TT(n=186) CC+CT(n=497) P3 干预组(n=100) 对照组(n=86) d P1 干预组(n=277) 对照组(n=220) d P2 空腹血糖前后 差值(mmol/L) -0.01±1.40* -0.15±0.77 0.14±1.13 0.562 0.31±1.22 0.05±1.04 0.26±1.09 0.008 <0.001 糖化血红蛋白值 前后差值(%) -0.27±1.20* 0.02±0.47 -0.29±0.89 0.045 0.03±1.98 0.12±0.50 -0.09±1.34 0.122 <0.001