基于结直肠癌细胞系MIC50相关基因对的基础耐药 评分模型构建

陈湖星, 徐蕾, 李静, 郭政, 敖露

The development of a general drug resistance score model based on MIC50 related gene pairs in colorectal cancer cell lines

Chen Huxing, Xu Lei, Li Jing, Guo Zheng, Ao Lu

表3 每个MCODE涉及基因的通路富集

Table 3 Pathway enrichment of genes that each MCODE involves

MCODE 通路ID 通路名称 Log10(P)值 1 R-HSA-373076 视紫红质样受体(class A/1 (rhodopsin-like receptors)) -16.9 1 R-HSA-418594 G alpha (i)信号事件(G alpha (i) signalling events) -16 1 R-HSA-500792 GPCR配体结合(GPCR ligand binding) -15.5 2 hsa00240 嘧啶代谢(pyrimidine metabolism) -5.8 2 hsa01200 碳代谢(carbon metabolism) -5.7 2 GO:0019693 磷酸核糖代谢过程(ribose phosphate metabolic process) -5.3 3 R-HSA-416476 G alpha (q)信号事件(G alpha (q) signalling events) -10.3 3 R-HSA-500792 GPCR配体结合(GPCR ligand binding) -6.2 3 R-HSA-375276 肽配体结合受体(peptide ligand-binding receptors) -5.3 4 R-HSA-72163 mRNA剪接-主要途径(mRNA Splicing-Major Pathway) -8.5 4 R-HSA-72172 mRNA剪接(mRNA Splicing) -8.4 4 R-HSA-72203 mRNA前体加工(processing of capped intron-containing pre-mRNA) -8.0