DNA甲基化驱动的转录表达特征作为肝癌预后预测标志物的价值

骆红波, 曹鹏博, 周钢桥

Prognostic and predictive value of a DNA methylation-driven transcriptional signature in hepatocellular carcinoma

Luo Hongbo, Cao Pengbo, Zhou Gangqiao

表2 10个最优基因的Cox比例风险回归分析结果、LASSO回归系数和基因组变异频率

Table 2 The results of Cox proportional hazard model analysis, LASSO regression coefficients and genetic alteration of the 10 optimal genes

基因 HR (95% CI) P值 LASSO系数 基因组变异频率(%) CDCA8 2.21 (1.54~3.01) <0.0001 0.1194 0.0 PRC1 1.85 (1.29~2.54) 0.0005 0.08869 0.3 MAPT 1.72 (1.21~2.46) 0.0021 0.2597 1.7 SFN 1.72 (1.21~2.45) 0.0021 0.001652 0.3 STC2 1.73 (1.22~2.43) 0.0021 0.03600 0.8 MYO18B 1.69 (1.19~2.37) 0.0031 0.1932 4.0 PBK 1.67 (1.17~2.35) 0.0036 0.06524 6.0 MAEL 1.55 (1.09~2.17) 0.013 -0.1766 10.0 TTC39A 1.55 (1.09~2.17) 0.013 -0.01347 1.4 LPL 1.55 (1.10~2.18) 0.014 0.003126 7.0