端粒长度与2型糖尿病：孟德尔随机化研究与多基因风险评分分析

曹岚, 李志强, 师咏勇, 刘赟

Telomere length and type 2 diabetes: Mendelian randomization study and polygenic risk score analysis

Cao Lan, Li Zhiqiang, Shi Yongyong, Liu Yun

表1 与端粒长度相关的遗传变异

Table 1 Previously published variants associated with telomere length

SNP Chr. 临近基因 效应等位基因 MAF 端粒长度 T2D β* P值 β P值 rs10936599 3 TERC C 0.252 0.117 2.54×10-31 -0.038 0.53 rs2736100 5 TERT C 0.486 0.094 4.38×10-19 -0.053 0.37 rs7675998 4 NAF1 G 0.217 0.090 4.35×10-16 -0.077 0.32 rs4387287 10 OBFC1 A NA 0.100 2.33×10-11 -0.114 0.17 rs8105767 19 ZNF208 G 0.291 0.058 1.11×10-09 -0.027 0.69 rs755017 20 RTEL1 G 0.131 0.074 6.71×10-09 0.095 0.12 rs3027234 17 CTC1 C 0.179 0.057 2.29×10-08 -0.323 0.04 rs11125529 2 ACYP2 A 0.142 0.067 4.48×10-08 0.135 0.08