选择性多聚腺苷酸化的生物学效应及其调控机制研究进展

徐海冬, 宁博林, 牟芳, 李辉, 王宁

Advances of functional consequences and regulation mechanisms of alternative cleavage and polyadenylation

Xu Haidong, Ning Bolin, Mu Fang, Li Hui, Wang Ning

图1 C/P反应的顺式调控元件和反式作用因子 CPSF：剪切多聚腺苷酸化特异因子(cleavage and polyadenylation specificity factor);CSTF：剪切激活因子(cleavage stimulation factor);CFIIm：剪切因子复合物I (cleavage factor I m);RBP：RNA结合蛋白(RNA binding protein);RNAP II：RNA聚合酶II(RNA polymerase II);PAP：poly(A)聚合酶(poly(A) polymerase);PABPN1：核poly(A)结合蛋白(nuclear poly(A)-binding protein 1);WDR33：WD重复域33 (WD repeat domain 33);FIP1：PAP互作因子(factor interacting with PAP);CLP1：C/P因子亚基1 (cleavage factor polyribonucleotide kinase subunit 1);PCF11：C/P因子亚基(cleavage and polyadenylation factor subunit);PAS：多聚腺苷酸化信号(polyadenylation signal)。根据参考文献[1, 8~10]总结绘制。

Fig. 1 The cis-acting regulatory elements and trans-acting factors involved in cleavage and polyadenylation (C/P)