选择性多聚腺苷酸化的生物学效应及其调控机制研究进展

徐海冬, 宁博林, 牟芳, 李辉, 王宁

Advances of functional consequences and regulation mechanisms of alternative cleavage and polyadenylation

Xu Haidong, Ning Bolin, Mu Fang, Li Hui, Wang Ning

图2 PAS类型及其APA示意图 PAS：多聚腺苷酸化信号(polyadenylation signal);CR-PAS：编码区PAS (coding region PAS);UTR-PAS：非编码区PAS (untranslated region PAS);TSS：转录起始位点(transcriptional start site);CDS：蛋白质编码区(coding sequence);RBP：RNA结合蛋白(RNA binding protein);lncRNA：长链非编码RNA (long non-coding RNA)。

Fig. 2 Schematic of different types of PAS and the APA events