溶藻弧菌群体基因组学研究

郑宏源, 闫琳, 杨超, 武雅蓉, 秦婧靓, 郝彤宇, 杨大进, 郭云昌, 裴晓燕, 赵彤言, 崔玉军

Population genomics study of Vibrio alginolyticus

Zheng Hongyuan, Yan Lin, Yang Chao, Wu Yarong, Qin Jingliang, Hao Tongyu, Yang Dajin, Guo Yunchang, Pei Xiaoyan, Zhao Tongyan, Cui Yujun

表4 溶藻弧菌耐药基因与相关抗生素和耐药机制

Table 4 Antimicrobial resistance genes and related antibiotics, resistance mechanisms of V. alginolyticus

耐药基因 耐受抗生素 耐药机制 blaCARB-42(99%) blaVEB-1(1%) Beta-lactam resistance Antibiotic inactivation E.coli_parE(100%) QnrVC1(6%) QnrA1(1%) QnrS5(1%) QnrVC5(1%) Quinolone resistance Antibiotic target alteration (parE) Antibiotic target protection (qnr) tet(35)(100%) tet(34)(98%) TxR(34%) tet(59)(1%) Tetracycline resistance Antibiotic efflux ANT(2'')-Ia(2%) APH(3'')-Ib(2%) APH(6)-Id(2%) ANT(3'')-IIa(1%) APH(3')-Ia(1%) Aminoglycoside antibiotic Antibiotic inactivation fos(5%) Fosfomycin resistance Antibiotic inactivation sul1(2%) sul2(2%) Sulfonamide antibiotic Antibiotic target replacement cmlA5(1%) floR(1%) catA3(1%) Phenicol antibiotic Antibiotic efflux (cmlA5, floR) Antibiotic inactivation (catA3) Ere(A)(1%) mph(A)(1%) Macrolide antibiotic Antibiotic inactivation arr-2(1%) Rifamycin antibiotic Antibiotic inactivation dfrA15(1%) dfrA31(1%) Trimethoprim resistant Antibiotic target replacement BRP(MBL)(1%) Glycopeptide antibiotic Antibiotic inactivation CRP(100%) rsmA(98%) ARG_regulator Antibiotic efflux qacEdelta1(2%) Quaternary ammonium compounds Antibiotic efflux