孤独症谱系障碍小鼠模型行为学检测方法

王剑飞, 韩俊海, 张子超

Behavioral analyses in mouse models of autism spectrum disorders

Wang Jianfei, Han Junhai, Zhang Zichao

表1 ASD小鼠模型社交行为检测

Table 1 Detection of social behaviors in ASD mouse models

小鼠模型	基因ID	三厢社交实验	居住者-入侵者实验	筑巢实验	母子分离/求偶实验	参考文献
Mecp2^-/y	17257	T_E >T_S, T_S2< T_S1		S=0.5WT	N_U、T_U↑, C_u↓	[58,59]
Shank1	243961	T_E<T_S	N_S=WT		N_U1↓	[60]
Shank2^-/-	210274	T_E>T_S, T_S2>T_S1		S=0.5WT	N_U、N_U1↓	[12,61]
Shank3^e4-9	58234	T_E>T_S, T_S2<T_S1			N_U1↓	[62]
Shank3^e13	58234	T_E<T_S, T_S2<T_S1	N_S=WT			[63,64]
Shank3B^-/-	58234	T_E>T_S, T_S2≈T_S1	N_S=0.5WT			[65]
Fmr1^-/y	14265	T_E>T_S, T_S2<T_S1	N_A=4WT, N_S=2WT		N_U、T_U、N_U1、T_U1↓	[66~68]
Trim32^-/-	69807	T_E<T_S, T_S2≈T_S1	N_S=0.5WT	S=0.6WT		[35]
Gabrb3^+/-	14402	T_E>T_S, T_S2<T_S1		S=0.6WT		[59,69]
Arid1b^+/-	239985	T_E≈T_S, T_S2<T_S1	N_S=0.6WT		T_U↑	[48,70]
Pax2^+/-	18504	T_E<T_S				[71]
Syngap^+/-	240057	T_E≈T_S, T_S2≈T_S1	N_S=0.9WT			[72]
Cntnap2^-/-	66797	T_E≈T_S		S=0.3WT	N_U、N_U1↓	[12,73]
Chd8^+/-	67772	T_E<T_S, T_S2>T_S1	N_S=WT	S=WT		[74,75]
Cttnbp2^-/-	30785	T_E≈T_S, T_S2≈T_S1	N_S=0.5WT		N_U、T_U↓	[76]
Dlg2^-/-	23859	T_E≈T_S, T_S2>T_S1	N_S=0.5WT			[77]
Nexmif ^-/-	2455555	T_E≈T_S, T_S2≈ T_S1				[78]
Nrxn1α^-/-	18189	T_E<T_S, T_S2>T_S1	N_A=3WT		N_U、T_U↓, C_u↓	[79,80]
Nlgn3^R451C	245537	T_E<T_S, T_S2>T_S1	N_A=2WT		N_U、N_U1↓	[81,82]
Nlgn4^-/-	100113365	T_E>T_S, T_S2<T_S1	N_A=0.5WT	S=0.7WT	N_U1↓	[83]
Nlgn1^-/-	192167	T_E<T_S, T_S2<T_S1	N_S=0.7WT	S=0.6WT	N_U↑	[84,85]
Pten^+/-	19211	T_E≈T_S, T_S2≈T_S1	N_A>10WT		N_U、T_U↓	[86,87]
Pten^-/-	19211	T_E≈T_S	N_S=0.5WT			[86]
Tsc1^-/- Tsc1^+/-	64930	T_E≈T_S, T_S2≈T_S1				[88]
Tsc2^+/-	22084	T_E≈T_S, T_S2≈T_S1				[89]
CBP^ΔCH1/ΔCH1	94212	T_E≈T_S	N_A=2WT	S=0.5WT		[90]
En2^-/-	13799		N_S=0.3WT			[91]
4E-BP2^-/-	13688	T_E>T_S			N_U、T_U↑, C_u、N_U1↓	[12,44]
Oxt^-/-	18429	T_E<T_S, T_S2>T_S			N_U、T_U↓	[92]
Foxp2	114142		N_S=0.6WT		N_U↓	[93,94]
15q11-13		T_E≈T_S, T_S2≈T_S1			N_U↑, N_U1↓	[95]
17p11.2		T_E<T_S, T_S2>T_S	N_A=6WT	S=0.5WT	N_U、T_U↓	[96,97]
VPA		T_E≈T_S	N_S=0.6WT			[98]
BTBR		T_E>T_S, T_S2<T_S1	N_S=0.4WT		N_U、T_U↑, C_u、N_U1↓	[99]
BALB		T_E>T_S, T_S2>T_S1	N_S↓			[100]
C58/J		T_E>T_S, T_S2>T_S1			T_U↓	[101]