孤独症谱系障碍小鼠模型行为学检测方法

王剑飞, 韩俊海, 张子超

Behavioral analyses in mouse models of autism spectrum disorders

Wang Jianfei, Han Junhai, Zhang Zichao

表3 ASD小鼠焦虑、学习记忆行为检测

Table 3 Detection of anxiety, learning and memory in ASD mouse models

小鼠模型 基因ID 旷场实验 高架十字迷宫实验 明暗穿梭实验 新事物识别实验 水迷宫实验 参考文献 Mecp2-/y 17257 Rt=0.5WT Rto=0.5WT TN>TF [58,59] Shank1 243961 Rt=0.6WT Rto=WT Nl=0.5WT TN>TF TL=WT, NT=WT [60] Shank2-/- 210274 Rto=0.5WT TN>TF TL=1.5WT, NT=0.5WT [12,61] Shank3e4-9 58234 V=0.5WT Tl=WT TL>1.5WT, NT<WT [62] Shank3e13 58234 Rt=0.7WT Rto=0.5WT Tl=WT TL=WT, NT=WT [63,64] Shank3B-/- 58234 Rto=0.5WT TL=1.6WT, NT=0.25WT [65] Arid1b+/- 239985 V=0.25WT Rto=0.25WT Tl=0.6WT TN=TF TL=3WT, NT=0.4WT [48,70] Pax2+/- 18504 Rto=WT [71] Syngap+/- 240057 Rt=1.3WT Rto=1.5WT Tl=WT [72] Cntnap2-/- 66797 V=1.5WT Tl=WT TL=WT, NT=WT [12,73] Chd8+/- 67772 Rt=0.5WT Rto=0.3WT Tl= 0.66WT [74,75] Cttnbp2-/- 30785 Rt=1.2WT Rto=1.3WT TN=TF [76] Dlg2-/- 23859 Rt=0.5WT Rto=WT Tl=0.5WT [77] Nexmif -/- 2455555 Rt=2WT [78] Nrxn1α-/- 18189 Rt=WT Rto=WT TL=WT, NT=WT [79,80] Nlgn3R451C 245537 Rt=WT Rto=WT Tl=WT [81,82] Nlgn4-/- 100113365 Rt=WT Rto=WT TL=WT, NT=WT [83] Nlgn1-/- 192167 Rt=WT Rto=WT Tl=WT TN>TF TL=WT, NT=0.3WT [84,85] Pten-/- 19211 Rt=0.5WT TL=WT, NT=WT [88] Tsc2+/- 22084 Rt=0.5WT TL=1.5WT, NT=0.5WT [89] CBPΔCH1/ΔCH1 94212 Rt=WT Rto=WT TN=TF [90] En2-/- 13799 TN<TF TL=2WT, NT=0.7WT [91] 4E-BP2-/- 13688 Rt=WT Rto=WT Nl=0.5WT [12,44] Foxp2 Rt=WT Rto=WT [95] 15q11-13 TL=WT, NT=WT [96,97] 17p11.2 Rt=0.7WT Rto=0.5WT [98] VPA Rt=0.2WT Rto=0.5WT TL=3WT, NT=0.3WT [99] BTBR Rt=0.5WT Rto=0.7WT Tl=WT TN<TF TL=WT, NT=0.8WT [100] C58/J Rt=0.5WT Rto=0.5WT TN<TF [101]