核辅激活因子PGC-1作用分子机制的研究进展

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HEREDITAS ›› 2005, Vol. 27 ›› Issue (2): 302-308.

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Progress in the Molecular Mechanisms of Nuclear Coactivator PGC-1

SUN Liang1~3;JIN Feng2;WANG Li2;YANG Ze1

1.Institute of Geriatrics, Ministry of Health, Beijing Hospital, Beijing 100730,China;2.Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101,China;3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

Received:2004-09-30 Revised:2004-12-03 Online:2005-04-10 Published:2005-04-10
Contact: YANG Ze

Abstract

Abstract: Peroxisome proliferators-activated receptor-γ coactivator-1 is broadly involved in several key cellular pathways including mitochondrial biogenesis, hepatic gluconeogenesis via interacting with many transcription factors, which is highly valuable to maintain the energy balance of organisms. This review especially focuses on the recent progress in the molecular docking, histone acetylation, RNA processing basing on the structure of PGC-1 gene and amino acid sequence. Besides, the prospect of PGC-1 in applications of metabolic syndromes has been discussed also.

Key words: PGC-1, coactivator, transcription regulation, histone acetylation, p38 MAPK

CLC Number:

Q493

SUN Liang~, JIN Feng, WANG Li, YANG Ze. Progress in the Molecular Mechanisms of Nuclear Coactivator PGC-1[J]. HEREDITAS, 2005, 27(2): 302-308.

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Progress in the Molecular Mechanisms of Nuclear Coactivator PGC-1

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