Hippo信号通路在肠道稳态、再生及癌变过程中的作用及机制

doi:10.16288/j.yczz.17-048

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 588-596.doi: 10.16288/j.yczz.17-048

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Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis

Yuan Gu¹(),Lei Zhang²,Faxing Yu¹(),

1. Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
2. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received:2017-02-17 Revised:2017-04-10 Online:2017-07-20 Published:2017-05-23
Supported by:
the National Natural Science Foundation of China(81622038,31571479)

Abstract

Abstract:

The intestine is an important digestive organ. Intestinal diseases such as acute or chronic enteritis and colorectal cancer pose a great threat to human health, which endows the studies related to intestine with great scientific and clinical value. The Hippo signaling pathway plays an important role in proliferation and differentiation of intestinal stem cells, and is involved in diverse physiological and pathological processes in the intestine. In this review, we summarize known functions and mechanisms of the Hippo signaling pathway in intestinal regeneration and tumorigenesis, provide a prospective on future research directions, and discuss potential therapeutic strategies targeting the Hippo signaling pathway.

Key words: intestine, Hippo signaling pathway, YAP, regeneration, colorectal cancer

Yuan Gu, Lei Zhang, Faxing Yu. Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis[J]. Hereditas(Beijing), 2017, 39(7): 588-596.

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