MST1/2调控先天免疫的功能和机制

doi:10.16288/j.yczz.17-066

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 642-649.doi: 10.16288/j.yczz.17-066

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The roles and mechanisms of MST1/2 in the innate immune response

Xin Zhou(),Weiyun Li,Hongyan Wang()

CAS Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China

Received:2017-02-28 Revised:2017-03-22 Online:2017-07-20 Published:2017-06-28
Supported by:
the National Natural Science Foundation of China(81571617, 31300723, 81671572, 31422018);the Strategic Priority Research Program of the Chinese Academy of Sciences Center for Excellence in Molecular Cell Science(XDB19000000);the Ministry of Science and Technology of China(2016YFD0500207, 2016YFC0902200)

Abstract

Abstract:

The Hippo signaling pathway regulates cell proliferation, organ size and tissue regeneration through a series of kinase cascades. MST1/2 is the mammalian orthologue of the core kinase Hippo, which is crucial for the activation of downstream signaling. Additionally, MST1/2 has been reported to play important roles in cell differentiation, morphology and cytoskeleton reorganization. Recent evidence suggests that MST1/2 is involved in the regulation of T cell adhesion, migration, homing and Treg cell maturation and functions. Interestingly, these processes are not dependent on the canonical, but a non-canonical Hippo signaling pathway. More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production. MST1/2 is associated with various diseases, such as bacterial or viral infection, inflammation-related cancer, and atherosclerosis. In this review, we summarize recent findings on the functions of MST1/2 in the innate immune response and inflammation-related diseases.

Key words: Hippo signaling pathway, MST1/2, innate immune, macrophage, inflammation-related disease

Xin Zhou,Weiyun Li,Hongyan Wang. The roles and mechanisms of MST1/2 in the innate immune response[J]. Hereditas(Beijing), 2017, 39(7): 642-649.

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The roles and mechanisms of MST1/2 in the innate immune response

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