基因组编辑技术在猪遗传改良中的应用

doi:10.16288/j.yczz.17-130

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (11): 1078-1089.doi: 10.16288/j.yczz.17-130

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Genome editing technologies drive the development of pig genetic improvement

Jiaojiao Huang¹(),Chunwei Cao¹,Guomin Zheng³,Jianguo Zhao^1,²()

1. State Key Lab of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2. University of Chinese Academy of Sciences, Beijing 100101, China
3. Company of Rongchang Breeding, Binzhou 251900, China

Received:2017-04-07 Revised:2017-05-19 Online:2017-11-20 Published:2017-12-20
Supported by:
the National Natural Science Foundation of China(81671274, 31402045, 31601008);the National Science and Technology Major Project of the Ministry of Science and Technology of China(2016ZX08009003-006-007);the Strategic Pilot Program of the Chinese Academy of Sciences(XDA08010304)

Abstract

Abstract:

Nuclease-mediated genome editing technologies contribute to the rapid advances in life sciences via the ability to edit the genomes within living cells, and present a new era for porcine genetic improvement. In this review, we introduce the development of various genomic editing technologies, particularly CRISPR/Cas9 strategies and characteristics of various naturally occurring and artificially engineered CRISPR enzymes. Also, we summarize progress in pig genetic improvement mediated by genome editing, especially those associated with meat quality traits and anti-virus resistance. We highlight the challenges in the implementation of pig genetic improvement and the prospects of pig genetic breeding based on genome editing technologies.

Key words: pig, genomic editing, genetic improvement

Jiaojiao Huang, Chunwei Cao, Guomin Zheng, Jianguo Zhao. Genome editing technologies drive the development of pig genetic improvement[J]. Hereditas(Beijing), 2017, 39(11): 1078-1089.

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