基因编辑技术及其在中国的研究发展

doi:10.16288/j.yczz.18-195

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (10): 900-915.doi: 10.16288/j.yczz.18-195

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Gene editing technology and its research progress in China

Yiou Chen^1,^4,⁵(), Ying Bao¹, Huazheng Ma¹, Zongyi Yi^1,^4,⁵, Zhuo Zhou^1,^2,^3,⁶, Wensheng Wei^1,^2,^3,^4,⁶()

^1. School of Life Science, Peking University, Beijing 100871, China
^2. Biomedical Pioneering Innovation Center, Peking University, Beijing 100871, China
^3. Beijing Advanced Innovation Center of Genomics, Beijing 100871, China
^4. PKU-Tsinghua Center for Life Sciences, Beijing 100871, China
^5. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
^6. Peking University Genome Editing Research Center, Beijing 100871, China

Received:2018-07-10 Revised:2018-09-07 Online:2018-10-20 Published:2018-09-11
Supported by:
the National Natural Science Foundation of China(31430025)

Abstract

Abstract:

Gene editing is a technology for precision modification of genome sequences or expressing transcripts. Early versions of such techniques include homing endonuclease, zinc finger endonuclease and transcription-like activator effectors. The CRISPR/Cas9 system has recently emerged as a powerful and versatile gene editing tool for a broad spectrum of applications. In this review, we discuss the recent development and applications of gene editing technology, and particularly focus on the progress in China, with the emphasis on mechanistic studies, development of new and extended technologies, the applications in animals, plants and the therapeutics.

Key words: gene editing, genetic engineering, CRISPR, gene function, disease model, gene therapy

Yiou Chen, Ying Bao, Huazheng Ma, Zongyi Yi, Zhuo Zhou, Wensheng Wei. Gene editing technology and its research progress in China[J]. Hereditas(Beijing), 2018, 40(10): 900-915.

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